Evidence map›Paper›PMID 40837630›Full record

ArticleAfrican health sciences2025

Inhibition of metallo-β-lactamases in carbapenem resistant Gram negative bacilli by omeprazole and pantoprazole.

Eman M Omar, Hisham A Abbas, Mona A Elsayed, Samar S Elbaramawi, Nada A Noureldin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Revisiting the Metallo-International journal of microbiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eman M OmarDepartment of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Hisham A AbbasDepartment of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Mona A ElsayedDepartment of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Samar S ElbaramawiDepartment of Medicinal Chemistry , Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Nada A NoureldinDepartment of Medicinal Chemistry , Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carbapenems are the most commonly used antibiotics for severe infections induced by metallo-beta-lactamases producing Enterobacteriaceae and Objectives: Detection and inhibition of MBLs production as a promising approach to overcome resistance to carbapenems. Methods: 160 clinical isolates of Results: Omeprazole and pantoprazole reduced the hydrolytic activities of MBLs. Both drugs had synergistic effects with meropenem. Meropenem minimum inhibitory concentration decreased in the presence of pantoprazole (2-16) folds, and omeprazole (2-32) folds. The metallo-β-lactamases genes Conclusion: The combination between meropenem and omeprazole or pantoprazole could be useful for treating infections caused by MBLs producing bacteria.

Indexed as

Anti-Bacterial Agentsbeta-Lactamase Inhibitorsbeta-LactamasesCarbapenemsGram-Negative BacteriaOmeprazolePantoprazoleEscherichia coliHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsPseudomonas aeruginosaAnti-Bacterial Agentsbeta-Lactamase Inhibitorsbeta-LactamasesCarbapenemsOmeprazolePantoprazoleEnterobacteriaceaeMeropenemMetallo-beta-lactamasesOmeprazolePantoprazolePseudomonas aeruginosa

Identifiers

PMID40837630
PMCPMC12361971

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.