Evidence map›Paper›PMID 40837586›Full record

ArticleFrontiers in immunology2025

Heterogeneity of CD8αα intraepithelial lymphocytes is transcriptionally conserved between TCRαβ and TCRγδ cell lineages.

Kaito A Hioki, Xueting Liang, Adam C Lynch, Ravi Ranjan, Elena L Pobezinskaya, Leonid A Pobezinsky

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Kaito A HiokiMolecular and Cellular Biology Program, University of Massachusetts, Amherst, MA, United States.
Xueting LiangDepartment of Veterinary and Animal Science, University of Massachusetts, Amherst, MA, United States.
Adam C LynchDepartment of Veterinary and Animal Science, University of Massachusetts, Amherst, MA, United States.
Ravi RanjanGenomics Resource Laboratory, Institute for Applied Life Sciences, University of Massachusetts, Amherst, MA, United States.
Elena L PobezinskayaDepartment of Veterinary and Animal Science, University of Massachusetts, Amherst, MA, United States.
Leonid A PobezinskyMolecular and Cellular Biology Program, University of Massachusetts, Amherst, MA, United States.

Funding

Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Defining post-transcriptional mechanisms that control CD8 T cell longevity, proliferation and differentiationR01AI146188 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI POBEZINSKIY, LEONID · 2020 to 2024
$2.7M
Cellular Engineering Biotechnology Training ProgramT32GM108556 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI HARDY, JEANNE ANN, PEYTON, SHELLY R. · 2015 to 2019
$766k
Defining the role of let-7 miRNAs in the differentiation of exhausted and memory T cellsR21AI133041 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI POBEZINSKIY, LEONID · 2018 to 2019
$444k
NIAID NIH HHS R01 AI146188NIAID NIH HHS R21 AI133041NIGMS NIH HHS T32 GM108556NIGMS NIH HHS T32 GM135096
6 · The paper itself

Abstract

Intestinal intraepithelial lymphocytes (IELs) are a versatile population of immune cells with both effector and regulatory roles in gut immunity. Although this functional diversity is thought to arise from distinct IEL subpopulations, the heterogeneity of TCRαβ

Indexed as

CD8 AntigensCell LineageIntraepithelial LymphocytesReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsAnimalsImmunologic MemoryIntestinal MucosaMiceMice, Inbred C57BLCD8 antigen, alpha chainCD8 AntigensReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaBLIMP1/Prdm1DN IELseffectorIEL - intraepithelial lymphocytememoryTCF1/Tcf7Vg7Zeb2 gene

Identifiers

PMID40837586
PMCPMC12361183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.