ArticleFrontiers in medicine2025
Serum uric acid predictive value and prognostic impact in rheumatoid arthritis' associated interstitial lung disease.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06036537 (Investigation on Risk Factors of Rheumatoid Arthritis Related Interstitial Lung Disease), which is not on this map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation on Risk Factors of Rheumatoid Arthritis Related Interstitial Lung Disease
Who cites it
2 citing papers in PubMed.
- Persistent Airway Uric Acid is Associated with Epithelial Stress Signaling and Macrophage Inflammatory Activation in COPD.Journal of inflammation research · 2026Article
- The Dual Role of Uric Acid: Pathological Implications Across Chronic Diseases and Current Approaches to Hyperuricemia Management.Discoveries (Craiova, Romania)Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Importance: It is critical to identify novel biomarkers for the prediction and prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Objective: The objective of the study was to investigate the predictive and prognostic significance of serum uric acid (UA) in RA-ILD. Design setting and participants: In this multicenter retrospective cohort study, demographic data, medical history, and laboratory results of 829 RA patients were extracted from electronic medical records between December 2018 and January 2024. The cohort was divided into an RA-ILD group ( Main outcomes and measures: The primary endpoint was the predictive capacity of baseline UA levels for the occurrence of ILD in RA patients. The secondary endpoints were all-cause mortality and the rehospitalization rate in RA-ILD patients. Results: The univariate analysis identified elevated levels of UA as a significant risk factor for the development of ILD in RA patients (OR [95% CI]: 1.68 [1.23-2.28], Conclusion and relevance: Elevated levels of serum UA may serve as a predictive marker for ILD development in RA patients, particularly in younger individuals without comorbidities, and a prognostic indicator for increased mortality and rehospitalization rates in RA-ILD patients. Clinical trial registration: ClinicalTrials.gov, identifier NCT06036537.
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