ReviewCureus2025
The Thermoregulatory Effect of Immediate Skin-to-Skin Contact for Preterm Infants: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal thermoregulation poses a considerable challenge, particularly in premature or low-birth-weight infants. Skin-to-skin contact (SSC) is now a recommended strategy to maintain thermoregulation in term infants. Current evidence shows promising results for the application of immediate SSC in preterm infants. A systematic review and meta-analysis synthesizing evidence from randomized controlled trials (RCTs) obtained from PubMed, Google Scholar, CENTRAL, Scopus, and Web of Science until May 2025. Using Stata MP v. 17 (StataCorp LLC, College Station, TX, US), we pooled dichotomous outcomes and continuous outcomes, using relative risk (RR) and standardized mean difference, respectively, along with a 95% confidence interval (CI). Five trials and 401 patients were included in our analysis. Temperature was significantly lower in the SSC group after 60 minutes (MD: -0.21, 95% CI (-0.30, -0.12), P < 0.001). However, there was no significant difference between the two groups regarding hypothermia (RR: 1.23, 95% CI (0.71, 2.16), P = 0.46) and hyperthermia (RR: 0.73, 95% CI (0.52, 1.03), P = 0.07). Also, there was no significant difference between both groups regarding hypoglycemia (RR: 3.15, 95% CI (0.34, 29.37), P = 0.31), stability of the cardiorespiratory system in preterm infants (SCRIP) score (MD: 0.22, 95% CI (-0.10, 0.54), P = 0.18), breathing support (RR: 0.92, 95% CI (0.71, 1.22), P = 0.55), and surfactant administration (RR: 0.77, 95% CI (0.40, 1.45), P = 0.41). Immediate SSC for preterm infants showed a slight decrease in temperature after 60 minutes, showing promising tolerability. Still, despite uncertain evidence, this effect did not impact any other clinical outcome, including hypothermia, hyperthermia, hypoglycemia, SCRIP score, breathing support, or surfactant administration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.