Evidence map›Paper›PMID 40837525›Full record

ArticleCerebral circulation - cognition and behavior2025

The effect of visit-to-visit blood pressure variability on cognitive function: state-of the-art.

Michiaki Nagai, Isabel J Sible, Phillip J Tully, Sunny S Po, Tarun W Dasari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Increased blood pressure variability - A risk of Alzheimer's disease?Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  3. Visit-to-visit blood pressure variability, brain MRI measures, and cognition in non-demented older adults.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michiaki NagaiCardiovascular section, Department of Medicine, University of Oklahoma, Health Science Center, OK, USA.
Isabel J SibleDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Phillip J TullyFaculty of Medicine and Health, School of Psychology, Deakin University, Burwood, VIC, Australia.
Sunny S PoCardiovascular section, Department of Medicine, University of Oklahoma, Health Science Center, OK, USA.
Tarun W DasariCardiovascular section, Department of Medicine, University of Oklahoma, Health Science Center, OK, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Visit-to-visit blood pressure (BP) variability (VVV) is a risk factor for cognitive impairment and cognitive decline, but several studies have recently shown that VVV also increases the risk of Alzheimer's disease (AD). Although the relationship between VVV and AD has been extensively studied, its pathophysiology is instructive due to its association with vascular stiffness, cerebral circulatory failure, decreased cardiac function, and AD pathology such as amyloid β and tau-proteins. This review article focuses on the relationship between VVV and cognitive function and summarizes recent studies and the underlying pathophysiology that appears to be mediated by systemic hemodynamic disruption.

Indexed as

Alzheimer’s diseaseAmyloid betaHemodynamics cognitive impairmentTau-proteinVisit-to-visit blood pressure variability

Identifiers

PMID40837525
PMCPMC12362100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.