Evidence map›Paper›PMID 40837465›Full record

ArticleActa ortopedica brasileira2025

GENICULAR NERVE ABLATION IN KNEE OSTEOARTHRITIS: A RANDOMIZED PROSPECTIVE STUDY.

João Vital Arthur Maradona Oliveira Dias, Vitor Ricardo Alves Pereira de Moraes, Matheus Trindade Bruxelas de Freitas, Matheus Manolo Arouca, Guilherme Pereira Ocampos, Olavo Pires de Camargo, Márcia Uchoa de Rezende

Abstract read
In one paragraph

Article in Acta ortopedica brasileira, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

João Vital Arthur Maradona Oliveira DiasUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0004-9267-6987
Vitor Ricardo Alves Pereira de MoraesUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0003-7040-780X
Matheus Trindade Bruxelas de FreitasUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0009-0001-2535-3529
Matheus Manolo AroucaUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0002-0994-9680
Guilherme Pereira OcamposUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0003-0052-6769
Olavo Pires de CamargoUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0002-1128-7292
Márcia Uchoa de RezendeUniversidade de Sao Paulo, Faculdade de Medicina, Hospital das Clinicas, Instituto de Ortopedia e Traumatologia (HC-FMUSP), São Paulo, SP, Brazil.ORCID https://orcid.org/0000-0002-2020-9501

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To document the effects of genicular nerve ablation in patients with severe knee osteoarthritis (OAJ) at 1 and 3 months. Methods: Prospective, randomized, and controlled trial with 35 patients with grade IV knee osteoarthritis according to Kelgren & Lawrence, undergoing genicular nerve ablation with pulsed radiofrequency (PRF) or phenol. Outcomes were assessed at baseline, 1 month, and 3 months using the Numeric Rating Scale (NRS), the Knee Injury and Osteoarthritis Outcome Score (KOOS), the 30-Second Chair Stand Test (TSL30), and the Timed Up and Go (TUG) test. Results: The groups were similar at baseline. Both groups improved similarly up to 3 months (p<0.001). NRS decreased by an average of 30% from baseline to all subsequent assessments (p<0.05). TUG decreased between baseline and one month post-procedure (p=0.001), while TSL30 increased from baseline to one and three months (p<0.05). The average behavior of patients was equal between groups over the evaluations for all scores (p Interaction > 0.05). None of the scores differed between groups, regardless of the evaluation period (p Group > 0.05). Conclusions: Genicular nerve ablation in patients with severe OAJ can provide lasting improvements in pain, function, and quality of life. Both methods, phenol and radiofrequency, are effective.

Indexed as

Osteoarthritis, KneePainPhenolRadiofrequency Ablation

Identifiers

PMID40837465
PMCPMC12364514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.