Observational studyClinical interventions in aging2025
Association of Preoperative Frailty and Post-Induction Hypotension in Elderly Patients Undergoing Major Non-Cardiac Surgery: A Prospective Observational Cohort Study.
Observational study in Clinical interventions in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Post-Intubation Hypotension After Titrated Induction with Ciprofol versus Propofol in Older Adults Undergoing Non-Cardiac Surgery: A Randomized Controlled Trial.Clinical interventions in aging · 2026Trial
- Topical Airway Lidocaine Spray Reduces the 95% Effective Dose of Sufentanil for Blunting Hemodynamic Response to Tracheal Intubation in Elderly Patients: A Biased-Coin Up-and-Down Sequential Allocation Trial.Drug design, development and therapy · 2026Trial
- Prospective randomized study to assess the effect of intramuscular glycopyrrolate on hypotension prevention among elderly patients following subarachnoid block during lower limb surgeries.Bioinformation · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Post-induction hypotension (PIH) is one of the most common complications during general anesthesia, especially in elderly patients. Frailty, which describes age-related decrease of physiological capacity with increased susceptibility to stress, may be associated with PIH, when stress is brought by anesthetics. This study aimed to explore the association between preoperative frailty and PIH as well as postoperative complications. Patients and Methods: This study was a prospective observational cohort study. Elderly patients scheduled for elective non-cardiac surgery under general anesthesia were recruited from December 2019 to April 2022 in Peking Union Medical College Hospital. Preoperative frailty was assessed by FRAIL scale. The primary outcome was post-induction hypotension. Secondary outcome included postoperative complications, functional recovery, length of stay and hospital cost. Results: A total of 147 patients were included in the final analysis, of which 25 (17.0%) were considered frail. Frailty patients were generally older and suffered more from anemia, hypoalbuminemia, weakness, and orthostatic hypotension. The incidence of PIH was significantly higher in frail patients than non-frail elderly (80.0% vs 37.7%). Multivariable analysis revealed that frailty was associated with higher risk of PIH (aRR 1.72, 95% CI 1.20-2.47, P=0.003) after adjusting for baseline characteristics, surgical type and intraoperative medications. Comprehensive complication index within 30 days after surgery was significantly higher in frail patients. Conclusion: Frailty is associated with post-induction hypotension during general anesthesia in elderly patients undergoing non-cardiac surgery. Preoperative frailty assessment may help identify high-risk patients for better anesthesia plan.
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