Evidence map›Paper›PMID 40837375›Full record

ArticleACS catalysis2025

Diversification of Pharmaceuticals via Late-Stage Hydrazination.

Tongliang Zhou, Chaoyue Zhao, Shiyi Yang, Elwira Bisz, Błażej Dziuk, Roger Lalancette, Roman Szostak, Xin Hong, Michal Szostak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tongliang ZhouDepartment of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States.ORCID https://orcid.org/0000-0002-7334-7078
Chaoyue ZhaoCenter of Chemistry for Frontier Technologies, Department of Chemistry, State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, P.R. China; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P.R. China.
Shiyi YangDepartment of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States.
Elwira BiszDepartment of Chemistry, Opole University, 48 Oleska Street, Opole 45-052, Poland.ORCID https://orcid.org/0000-0002-7070-2468
Błażej DziukDepartment of Chemistry, University of Science and Technology, Norwida 4/6, Wroclaw 50-373, Poland.
Roger LalancetteDepartment of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States.ORCID https://orcid.org/0000-0002-3470-532X
Roman SzostakDepartment of Chemistry, Wroclaw University, F. Joliot-Curie 14, Wroclaw 50-383, Poland.
Xin HongCenter of Chemistry for Frontier Technologies, Department of Chemistry, State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou 310027, P.R. China; School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, P.R. China.ORCID https://orcid.org/0000-0003-4717-2814
Michal SzostakDepartment of Chemistry, Rutgers University, 73 Warren Street, Newark, New Jersey 07102, United States.ORCID https://orcid.org/0000-0002-9650-9690

Funding

Catalytic Methods for Organic SynthesisR35GM133326 · NIGMS · RUTGERS THE STATE UNIV OF NJ NEWARK · PI Michal Szostak · 2019 to 2026
$2.7M
NIGMS NIH HHS R35 GM133326
6 · The paper itself

Abstract

Developments in organic synthesis over the past century have greatly enabled the discovery of life-saving medicines. In this context, over the past two decades, palladium-catalyzed cross-coupling reactions have transformed the exploration of emerging therapeutics. However, the cross-coupling between aryl halides and hydrazine, NH

Indexed as

hydrazineimidazo[1,5-a]pyridin-3-ylidenelate-stage functionalizationN-heterocyclic carbeneprecatalyst

Identifiers

PMID40837375
PMCPMC12362435

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.