ArticleJournal of medical biochemistry2025
Elevated interleukin-10, -22, -24, and -26 in serum samples of children with infectious mononucleosis.
Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- IL-22 promotes the establishment of chronic gammaherpesvirus infection by supporting the germinal center response.PLoS pathogens · 2026Article
- Network analysis of Mycoplasma pneumoniae pneumonia and Epstein-Barr virus co-infection.BMC infectious diseases · 2026Article
- The clinical utility of combining D-dimer with the C-reactive protein/albumin ratio for assessing treatment response in pediatric infectious mononucleosis.Frontiers in medicine · 2026Article
- Immunological profile and its clinical implications in pediatric infectious mononucleosis.Frontiers in pediatrics · 2025Article
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Authors and funding
10 authors.
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Abstract
Background: Infectious mononucleosis (IM) is an infectious disease with different stages of onset, and the pathogenesis of IM remains unclear. This study aimed to investigate the levels of interleukin (IL)-10 family cytokines IL-10, -22, -24, and -26 in serum samples of patients with infectious mononucleosis (IM) and the potential diagnostic values. Methods: Thirty children with IM were enrolled in the study, and serum samples were collected; 30 healthy children served as the controls. Serum samples from the patients and healthy controls were collected, and IL-10, -22, -24, and -26 were determined by the ELISA method. An automatic biochemical analyser detected the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Moreover, potential diagnostic values of IL-10, -22, -24 and -26 have been analysed using ROC curve analysis, and the correlation between the levels of IL-10, -22, -24 and -26 in patients was analysed. Correlation between IL-10, -22, -24, and -26 and ALT and AST were analysed. Results: IL-10, -22, -24, and -26 levels increased in serum samples of patients with IM compared to healthy controls. ROC analysis showed that the AUC of IL-10, -22, -24, and -26 were 0.8500, 0.7078, 0.8056, and 0.9167, respectively, suggesting that IL-10, -22, -24, and -26 were good biomarkers. Moreover, IL-10, -22, -24 and -26 levels were positively correlated with the ALT and AST of the patients. Conclusions: IL-10, -22, -24, and -26 were upregulated in the serum of patients with IM, suggesting they may function as potential biomarkers.
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