Trial reportDrug design, development and therapy2025
The Effects of Low-Dose Esketamine Combined with Paravertebral Block on Postoperative Hyperalgesia and Enhanced Recovery in Non-Intubated Video-Assisted Thoracic Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative safety of esketamine in procedural sedation and analgesia: a systematic review and network meta-analysis.BMC anesthesiology · 2026Pooled it
- Ultrasound-Guided Femoral Nerve Block with Esketamine Adjuvant for Postoperative Analgesia in Total Knee Arthroplasty-A Randomized, Double-Blind, Controlled Trial.Drug design, development and therapy · 2026Trial
- Effect of Subanesthetic Doses of Esketamine on Early Postoperative Pain Sensitivity in Patients Undergoing Salpingectomy: A Randomized Clinical Trial.Drug design, development and therapy · 2026Trial
- Esketamine as an Adjuvant to Ropivacaine in Genicular Nerve and IPACK Blocks for Total Knee Arthroplasty: A Double-Blind Randomized Trial.Drug design, development and therapy · 2025Trial
- Chronic postsurgical pain in children: Current evidence and clinical perspectives.World journal of clinical pediatrics · 2026Review
- Recent advances in thoracic anesthesia: lung protection, airway management, and enhanced recovery-a narrative review.Journal of thoracic disease · 2026Review
- Non-intubated VATS under combined serratus anterior plane block for hemodynamically fragile post-CABG delayed pericardial effusion: a case report.BMC anesthesiology · 2026Article
- Clinical and Economic Outcomes of Liposomal Bupivacaine, Ropivacaine, and Patient-Controlled Intravenous Analgesia for Adult Video-Assisted Thoracoscopic Surgery: A Retraospective Cohort Study.Journal of pain research · 2026Article
- Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Non-intubated video-assisted thoracic surgery (NIVATS) reduces airway trauma but may lead to postoperative hyperalgesia and opioid dependence, contradicting enhanced recovery after surgery (ERAS) principles. We hypothesized that combining low-dose esketamine with a paravertebral block (PVB) may mitigate hyperalgesia, decrease opioid requirements, and improve recovery quality in NIVATS. Patients and Methods: This prospective single-center, double-blind randomized controlled trial (RCT) enrolled 82 patients undergoing uniportal NIVATS. Patients were randomized into two groups: esketamine (0.25 mg/kg pre-induction + 0.15 mg/kg/h intraoperatively) and control. Both groups received ultrasound-guided T4 and T6 PVB (with 0.375% ropivacaine). The primary outcome was mechanical pain threshold (MPT; central/peripheral), quantified preoperatively and at 0.5-48 h postoperatively using pressure algometry after laryngeal mask airway (LMA) removal. Secondary outcomes included quality of recovery-40 (QoR-40) scores, intraoperative sufentanil/norepinephrine use, postoperative rescue analgesia use, and other related complications. Results: Compared to controls, the esketamine group exhibited significantly higher MPT at 6 h postoperatively (central: 2.77 ± 0.80 vs 2.17 ± 0.59 kgf/cm², Conclusion: Low-dose esketamine combined with PVB attenuates postoperative hyperalgesia, reduces intraoperative opioid use by 71.4%, and enhances recovery in NIVATS, offering a clinically effective opioid-sparing strategy for ERAS protocols.
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