ArticleCurrent transplantation reports2023
The Functional Adaptability of Hyporesponsive T Cells and its Impact on Transplant Outcomes.
Article in Current transplantation reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Purpose of Review: The functional adaptability of hyporesponsive T cells in precluding transplant acceptance is not well recognized. This review aims to highlight the impact of this mechanism on transplant outcomes and explore potential strategies to overcome this challenge. Recent Findings: Hyporesponsive T cells exist in two major distinct states: anergy and exhaustion. In response to infection, alloreactive anergic T cells can differentiate into IFN-γ producing effector cells, leading to the abrogation of transplant acceptance. Depleting anergic T cells has been shown to promote transplant acceptance under infection. In addition, "precursor exhausted" T (T Summary: This review focuses on the functional adaptability of hyporesponsive T cells and highlights the importance of further investigations into strategies to disarm these cells. Such research could have significant clinical implications for transplant patients.
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Registered trials
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