Evidence map›Paper›PMID 40837234›Full record

ArticleiScience2025

Differentiation-associated ISG expression of NK cells in chronic viral infection.

Franziska Keller, Robert Lorenz Chua, Timo Trefzer, Katharina Jechow, Liane Bauersfeld, Fabian Beier, Sagar, Özlem Sogukpinar, Giuseppe Rusignuolo, Marta Rizzi and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Franziska KellerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Robert Lorenz ChuaCenter for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10178 Berlin, Germany.
Timo TrefzerCenter for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10178 Berlin, Germany.
Katharina JechowCenter for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10178 Berlin, Germany.
Liane BauersfeldDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Fabian BeierDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
SagarDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Özlem SogukpinarDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Giuseppe RusignuoloDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Marta RizziDepartment of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Roland EilsFaculty of Biology, University of Freiburg, 79104 Freiburg, Baden-Württemberg, Germany.
Andreas PichlmairTechnical University of Munich, School of Medicine, Institute of Virology, 81675 Munich, Bavaria, Germany.
Marco BinderResearch Group "Dynamics of Early Viral Infection and the Innate Antiviral Response", Division Virus-Associated Carcinogenesis (D430), German Cancer Research Center, 69120 Heidelberg, Baden-Württemberg, Germany.
Bertram BengschDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Christoph Neumann-HaefelinDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Volker LohmannDepartment of Infectious Diseases, Molecular Virology, Section Virus-Host-Interactions, University of Heidelberg, Heidelberg, Germany.
Tobias BoettlerDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Christian ConradCenter for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10178 Berlin, Germany.
Robert ThimmeDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.
Maike HofmannDepartment of Medicine II (Gastroenterology, Hepatology, Endocrinology and Infectious Diseases), Medical Center- University of Freiburg, 79106 Freiburg, Baden-Württemberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer (NK) cell responses are modulated by type-I interferons (IFNs) in viral infection. Chronic hepatitis C virus (HCV) infection, marked by robust IFN signatures, shows NK cells with reduced cytokine release but heightened cytotoxicity. Comparable alterations occur in chronic hepatitis B virus (HBV) infection even without a pronounced IFN milieu, implying additional regulatory layers. We analyzed NK cells from healthy donors and patients with chronic HBV or HCV and found conserved expression patterns of interferon-stimulated genes (ISGs) such as

Indexed as

ImmunologyTranscriptomics

Identifiers

PMID40837234
PMCPMC12362017

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.