ArticleNeurophotonics2025
Arterial-wall origin and transient dynamics of flow- and vaso-motion activities in the awake mouse brain revealed by laser speckle contrast imaging.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- Cardiac pulse transfer along the cerebral microvascular network captured by laser speckle contrast imaging.Biomedical optics express · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significance: Cerebral vasomotion and associated flowmotion are considered crucial for optimal brain perfusion and metabolic regulation, with reduced vasomotion being linked to cerebrovascular and neurodegenerative disorders. However, the underlying mechanisms and spatiotemporal dynamics of cerebral vasomotion are still poorly understood, underscoring the need for further research and methodological approaches for its comprehensive characterization. Aim: We aimed to develop an approach for comprehensively characterizing spatiotemporal vasomotion and flowmotion dynamics and apply it to study resting-state activity at vasomotion frequencies (0.05 to 0.25 Hz) in the awake mouse brain. Approach: Laser speckle contrast imaging (LSCI) was used to image cortical blood flow in awake mice with high spatiotemporal resolution. Pixel-wise wavelet transforms and pulsatility-based segmentation enabled the identification and quantification of transient events at the vasomotion frequency range. Results: We identified both vasomotion and flowmotion events, which displayed intermittent periods of high and low activity lasting Conclusions: Our data suggest the arterial wall origin of transient vasomotion events and their consequent propagation as flowmotion in the awake mouse brain. The combined use of pulsatility imaging, wavelet analysis, and temporal clustering in the LSCI analysis provides a framework for the comprehensive characterization of vasomotion-associated blood flow dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.