Evidence map›Paper›PMID 40837201›Full record

ArticleSmart medicine2025

Pollen Integrated Hydrogel Patches With Hierarchical Structures and Spatio-Temporal Actives Release for Wound Healing.

Xinyu Zhu, Lijun Cai, Yu Wang, Hong Chen, Chenjie Yu, Yuanjin Zhao

Abstract read
In one paragraph

Article in Smart medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. [Research progress on the application of pollen in the biomedical field].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xinyu ZhuDepartment of Otolaryngology Head and Neck Surgery Nanjing Drum Tower Hospital Clinical Medical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing China.ORCID https://orcid.org/0009-0002-0309-7613
Lijun CaiSchool of Biological Science and Medical Engineering Southeast University Nanjing China.
Yu WangSchool of Biological Science and Medical Engineering Southeast University Nanjing China.
Hong ChenDepartment of Otolaryngology Head and Neck Surgery Nanjing Drum Tower Hospital Research Institute of Otolaryngology Jiangsu Provincial Key Medical Discipline Affiliated Hospital of Medical School Nanjing University Nanjing China.ORCID https://orcid.org/0000-0001-5258-2012
Chenjie YuDepartment of Otolaryngology Head and Neck Surgery Nanjing Drum Tower Hospital Research Institute of Otolaryngology Jiangsu Provincial Key Medical Discipline Affiliated Hospital of Medical School Nanjing University Nanjing China.
Yuanjin ZhaoDepartment of Otolaryngology Head and Neck Surgery Nanjing Drum Tower Hospital Clinical Medical College of Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing China.ORCID https://orcid.org/0000-0001-9242-4000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogel patches have been serving as powerful tools for wound healing. Scientific attention in this field is focused on imparting the patches with novel structures, functions, and actives for promoting wound healing. In this paper, we have developed an innovative hydrogel patch with hierarchical structure and spatiotemporal actives release for efficient wound healing. This hydrogel patch was achieved by integrating asiatic acid (AA)-loaded pollens with chlorogenic acid (CA)-containing gelatin methacryloyl (GelMA) hydrogel. The high specific surface area and nanoporous structure of the pollens-integrated GelMA promote efficient loading and release of CA and AA, respectively. In wound treatment, the outer layer of GelMA first releases CA to fight infection. With the gradual degradation of GelMA, the pollens are exposed to the wounds and released AA, intensifying anti-inflammatory effects and promoting wound healing. These features indicate that this pollen-integrated hydrogel patch significantly accelerates the wound healing process in a spatiotemporal responsive manner, demonstrating great potential for clinical applications.

Indexed as

hierarchicalhydrogelpatchpollenwound healing

Identifiers

PMID40837201
PMCPMC12362785

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.