ReviewFrontiers in cell and developmental biology2025
The neural signature of high myopia: structural and functional brain alterations and their cognitive-emotional associations.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neuro-ophthalmic review on pediatric myopia: Advancing from refraction to a brain-centric model of axial growth.World journal of clinical pediatrics · 2026Review
- Cortical thickness and volume alterations in patients with high myopia: a magnetic resonance imaging study.BMC medical imaging · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond refractive error, myopia is increasingly recognized as a systemic condition with neurological implications, associated with visual dysfunction and structural retinal-choroidal alterations. This review synthesizes neuroimaging evidence demonstrating widespread neuroanatomical and functional brain changes in myopia, including cortical thinning, white matter disorganization, and disrupted functional connectivity, which may be associated with changes in cognitive-emotional systems rather than just the visual system. Mechanistically, these neural signatures reflect experience-dependent neural plasticity, dopaminergic dysregulation in the retinal ON pathway, and non-image-forming disruptions mediated by intrinsically photosensitive retinal ganglion cells, compounded by vascular dysfunction and impaired neurovascular coupling. Clinically, these findings highlight the importance of early neurocognitive risk assessment through multimodal imaging and psychological screening. By elucidating the retina-brain axis, this review bridges ophthalmological and neurological perspectives, guiding precision interventions for comprehensive, life-course myopia management.
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Registered trials
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