Evidence map›Paper›PMID 40837190›Full record

ArticleFrontiers in cell and developmental biology2025

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal.

Marius W Baeken, Ankush Borlepawar, Philipp Kötzner, Holger Richly, Christian Behl, Bernd Moosmann, Parvana Hajieva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marius W BaekenInstitute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Ankush BorlepawarCellular Adaptation and Bioenergetics Group, Institute for Translational Medicine (ITM), MSH Medical School Hamburg, Hamburg, Germany.
Philipp KötznerInstitute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Holger RichlyLaboratory of Molecular Epigenetics, Institute of Molecular Biology (IMB), Mainz, Germany.
Christian BehlInstitute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Bernd MoosmannInstitute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Parvana HajievaInstitute for Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different signaling pathways connect the mitochondrion with the transcriptional machinery in the nucleus. Redox events are thought to play a substantial role along this axis, however, many open questions about their specificity and mode of action remain. Here, we have employed subtoxic doses of the complex I inhibitor MPP

Indexed as

epigeneticsMPTPNADH dehydrogenaseParkinson’s diseaseperhydroxyl radicalredox signalingrespiratory chain

Identifiers

PMID40837190
PMCPMC12361244

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.