ArticleIndian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
Impact of Sociodemographic Factors on the Efficacy of Multidrug-resistant Tuberculosis Therapy in Russia: Retrospective Epidemiological Study.
Article in Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Russia has the highest prevalence of multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) in the world. This study aims to evaluate the impact of sociodemographic determinants on the effectiveness of therapy in patients with MDR/RR-TB in the Khabarovsk krai region of Russia. Methods: We conducted a retrospective cross-sectional epidemiological study. Using the centralized national database of TB patients, data was collected on 2661 patients diagnosed with TB from 2018 to 2019 in all medical facilities of the region. After applying exclusion criteria, the final sample consisted of 531 patients with determined MDR/RR and with a known chemotherapy outcome. The influence on the therapy outcome of the 13 variables was analyzed using a binary logistic regression. Results: 10 out 13 analyzed variables had no influence on a given therapy's effectiveness. These variables were sex, age, residence, occupation, substance abuse, presence of disability, circumstance of TB diagnosis, TB localization, HIV coinfection, and history of imprisonment. Previous treatment with Isoniazid and Rifampicin ( Conclusion: Our findings point to demographic restructuring of the core of MDR/RR-TB carriers in Russia. As a way to resolve this situation, we wish to emphasize shifting the focus from risk groups and facility-based therapy to home-based therapy, as well as focusing on combating the social stigma and further improving HIV care.
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