Evidence map›Paper›PMID 40837128›Full record

ArticleJGH open : an open access journal of gastroenterology and hepatology2025

Causal Relationship Between Mitochondrial Characteristics and Inflammatory Bowel Disease and Its Subtypes: Evidence for Mendelian Randomization.

Yichen Cai, Hancheng Fan, Jianmin Zhao, Guoxiang Fu

Abstract read
In one paragraph

Article in JGH open : an open access journal of gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yichen CaiDepartment of Pathology at Sir Run-Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China.ORCID https://orcid.org/0009-0009-7657-3888
Hancheng FanDepartment of Pathology at Sir Run-Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China.
Jianmin ZhaoDepartment of Pathology at Sir Run-Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China.
Guoxiang FuDepartment of Pathology at Sir Run-Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The research was designed to explore the causal relationship between the changing landscape of 63 mitochondrial proteins and inflammatory bowel disease (IBD) by Mendelian randomization. Methods: Use SNPs significantly associated with IBD and their subtypes as instrumental variables. Various methods were utilized to assess the causal relation between mitochondrial function and the onset of IBD and their subtypes. Results: The results after FDR on Conclusion: This study established a causal relationship between mitochondrial biological function and IBD, including its subtypes.

Indexed as

genome‐wide association studiesinflammatory bowel diseaseMendelian randomizationmitochondria

Identifiers

PMID40837128
PMCPMC12361811

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.