Evidence map›Paper›PMID 40837127›Full record

ArticleUrology case reports2025

Synchronous giant bilateral renal tumors as initial presentation of Von Hippel-Lindau disease: Sequential surgical management and transition to renal replacement therapy.

Alberto E Fuentes, Renato A Ramírez, Gabriela P Vera, Felipe A Del Valle, Alfonzo E Bruzzone, Francisco A Rojas, José P Arenas, Diego P Barrera

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alberto E FuentesPontificia Universidad Católica de Chile, Chile.
Renato A RamírezSchool of Medicine, Pontificia Universidad Católica de Chile, Chile.
Gabriela P VeraComplejo Asistencial Doctor Sótero del Río, Chile.
Felipe A Del ValleComplejo Asistencial Doctor Sótero del Río, Chile.
Alfonzo E BruzzoneComplejo Asistencial Doctor Sótero del Río, Chile.
Francisco A RojasComplejo Asistencial Doctor Sótero del Río, Chile.
José P ArenasComplejo Asistencial Doctor Sótero del Río, Chile.
Diego P BarreraComplejo Asistencial Doctor Sótero del Río, Chile.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synchronous bilateral renal cell carcinoma (RCC) is rare and often linked to hereditary syndromes such as Von Hippel-Lindau (VHL) disease. We present a 27-year-old male with acute appendicitis, whose CT incidentally revealed bilateral renal tumors and pancreatic cysts. Further evaluation identified cerebellar and retinal hemangioblastomas, confirming VHL. Due to tumor complexity, sequential laparoscopic radical nephrectomies were performed, followed by hemodialysis initiation and transplant planning. Pathology showed multifocal clear cell RCC, ISUP grades 2-3. This case illustrates an atypical VHL presentation, where early syndromic suspicion and multidisciplinary coordination enabled timely and effective management.

Indexed as

Bilateral renal tumorsClear cell renal cell carcinomaRadical nephrectomyVon Hippel-Lindau disease

Identifiers

PMID40837127
PMCPMC12362395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.