Evidence map›Paper›PMID 40837119›Full record

ArticleNano research2025

Advances in nanotechnology-enabled adjuvants for peptide-based cancer vaccines.

Mengwen Li, Wenpan Li, Zhi Li, Jianqin Lu

Abstract read
In one paragraph

Article in Nano research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mengwen LiSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Wenpan LiSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Zhi LiSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.
Jianqin LuSkaggs Pharmaceutical Sciences Center, Department of Pharmacology & Toxicology, R. Ken Coit College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0002-5877-619X

Funding

A fortified lipid bilayer platform for improved drug packaging and therapeutic deliveryR35GM147002 · NIGMS · UNIVERSITY OF ARIZONA · PI Jianqin Lu · 2022 to 2026
$1.9M
A Phospholipid-Derived Nanotherapeutic Platform for Improved Colorectal Cancer ImmunochemotherapyR01CA272487 · NCI · UNIVERSITY OF ARIZONA · PI Jianqin Lu · 2023 to 2026
$1.4M
NCI NIH HHS R01 CA272487NIGMS NIH HHS R35 GM147002
6 · The paper itself

Abstract

Peptide-based vaccines only contain peptide epitopes and exclude unnecessary biological materials, which greatly reduces the risk of causing an undesired immune response and further improves the safety profile, garnering considerable interest in vaccine development. However, the immunogenicity induced by these peptides alone is not potent enough to elicit an effective immune response. Recently, combining the adjuvants with peptide antigens has shown promising effects to realize a satisfying immune response. In this review, we discuss the development of immunoadjuvants to enhance the safety and efficacy of peptide-based vaccines. The emphasis is placed on the application and clinical translation of nanotechnology-based adjuvants, highlighting the associated challenges and exploring future directions.

Indexed as

adjuvantscancer vaccinenanotechnologypeptide-based vaccine

Identifiers

PMID40837119
PMCPMC12362341

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.