Evidence map›Paper›PMID 40837066›Full record

ArticleOphthalmology science

Longitudinal Assessment of Area of Reticular Pseudodrusen in Eyes with Age-Related Macular Degeneration.

Swetha Bindu Velaga, Ahmed Roshdy Alagorie, Muneeswar Gupta Nittala, Noel C Moore, Yeunjoo E Song, Jonathan Haines, Margaret A Pericak-Vance, Dwight Stambolian, Zhihong Hu, Ye He and 1 more

Abstract read
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In one paragraph

Article in Ophthalmology science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Swetha Bindu VelagaDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California.
Ahmed Roshdy AlagorieDepartment of Ophthalmology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Muneeswar Gupta NittalaDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California.
Noel C MooreDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
Yeunjoo E SongDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
Jonathan HainesDepartment of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio.
Margaret A Pericak-VanceJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida.
Dwight StambolianDepartment of Ophthalmology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania.
Zhihong HuDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California.
Ye HeDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California.
Srinivas R SaddaDoheny Eye Institute, University of California-Los Angeles, Los Angeles, California.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the change in the area of reticular pseudodrusen (RPD) and choroidal thickness over 2 years in eyes with age-related macular degeneration (AMD). Design: Longitudinal cohort study. Subjects: The study reviewed 1332 eyes from 666 subjects with baseline and 2-year follow-up data, of which 108 eyes were graded to have RPD. Among these, 35 eyes from 22 participants (mean age: 72.8 ± 8.9 years; range: 50-84; 37% female) were eligible for this analysis because they had early or intermediate AMD with RPD at baseline, absence of geographic atrophy at 2 years, and images that were gradable for the presence of RPD. Methods: Infrared reflectance (IR), blue-light fundus autofluorescence, and spectral-domain OCT were obtained for all subjects at baseline and at 2 years. Using the instrument software, a certified grader delineated the RPD area (mm Main Outcome Measures: Changes in RPD area (mm Results: The RPD area increased significantly ( Conclusions: In this longitudinal natural history analysis, we observed an increase in RPD area of >6 mm Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Age-related macular degenerationReticular pseudodrusen

Identifiers

PMID40837066
PMCPMC12363575

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.