ArticleEuropean journal of cancer care2025
Transcriptomic Profiles and Functional Correlates of Cancer-Related Fatigue: A Cross-Sectional Study in Women Undergoing Cancer Treatment.
Article in European journal of cancer care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Objectives: Cancer-related fatigue is a multifactorial condition that affects most people undergoing chemotherapy. To elucidate potential biological underpinnings of fatigue, this study tested correlations between patient-reported fatigue and (1) functional measures and (2) transcriptomics of whole blood. Methods: Women undergoing chemotherapy were recruited to a cross-sectional study. Participants reported subjective fatigue on the Functional Assessment for Chronic Illness Therapy-Fatigue (FACIT-F) and Brief Fatigue Inventory (BFI) questionnaires. Participants completed upper- and lower-body functional assessments as an objective fatigability measure. Fasted blood samples were analyzed for complete blood counts (CBCs) to quantify cell type, and RNA-Seq on whole blood was investigated for a distinct transcriptional signature in patients with high vs. low fatigue. Principal component analysis revealed that transcriptomic profiles clustered based on the neutrophil level, lymphocyte level, and several other clinical factors, which were accounted for when assessing differentially expressed genes. Results: Participants had breast (
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