Evidence map›Paper›PMID 40836995›Full record

ArticleOsteoarthritis imaging2025

Shear wave elastography reveals elevated infrapatellar fat pad stiffness in patients with early osteoarthritis symptoms after ACL reconstruction.

Matthew S Harkey, Corey D Grozier, Jessica Tolzman, Arjun Parmar, Toufic R Jildeh, Micah Lissy, Robert Dima, Harvi F Hart, Ryan Fajardo

Abstract read
In one paragraph

Article in Osteoarthritis imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew S HarkeyDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0002-3480-3173
Corey D GrozierDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Jessica TolzmanDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Arjun ParmarDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Toufic R JildehMichigan State University Sports Medicine, East Lansing, MI, USA.
Micah LissyMichigan State University Sports Medicine, East Lansing, MI, USA.
Robert DimaLawson Health Research Institute, St Joseph's Hospital, London, ON, Canada.
Harvi F HartDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Ryan FajardoLansing Radiology Associates, Lansing, MI, USA.

Funding

Walk this Way: Physical Activity and Walking Biomechanics Lead to Early Knee OA Symptoms and Ultrasound-Detected Structural Pathology after ACL ReconstructionK01AR081389 · NIAMS · MICHIGAN STATE UNIVERSITY · PI Matthew Harkey · 2022 to 2026
$689k
NIAMS NIH HHS K01 AR081389
6 · The paper itself

Abstract

Objective: The infrapatellar fat pad (IPFP) plays an important role in knee biomechanics and inflammation, particularly following anterior cruciate ligament reconstruction (ACLR). This study investigated whether IPFP stiffness, measured with shear wave elastography, is associated with early symptoms of osteoarthritis (OA) in individuals within one year after ACLR. Design: In this cross-sectional study, 24 participants underwent bilateral IPFP stiffness assessments using shear wave elastography. Participants were positioned supine with 20° knee flexion. The stiffness limb symmetry index (LSI) was calculated to normalize stiffness between the ACLR and contralateral limbs. Early OA symptoms were defined as scores ≤85 % on at least two of four subscales of the Knee Injury and Osteoarthritis Outcome Score (KOOS). Independent Results: Eleven participants (46 %) showed early OA symptoms. Participants with early OA symptoms exhibited a significantly higher IPFP stiffness LSI compared to those without symptoms (49.2 ± 48.7 % vs. -17.3 ± 34.4 %, Conclusions: Shear wave elastography shows potential as a non-invasive tool for detecting early IPFP stiffness changes associated with OA symptoms post-ACLR. These findings suggest that IPFP stiffness may be an early marker for OA risk, warranting further longitudinal studies to evaluate its progression and to further examine the clinical utility of shear wave elastography.

Indexed as

ACLRElastographyIPFPRehabilitationUltrasonography

Identifiers

PMID40836995
PMCPMC12362417

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.