Evidence map›Paper›PMID 40836950›Full record

ArticleAdvanced intelligent systems (Weinheim an der Bergstrasse, Germany)2025

Assessing Large Multimodal Models for One-Shot Learning and Interpretability in Biomedical Image Classification.

Wenpin Hou, Qi Liu, Huifang Ma, Yilong Qu, Zhicheng Ji

Abstract read
In one paragraph

Article in Advanced intelligent systems (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Lense: Optimizing data preprocessing in single-cell omics using LLMs.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Benchmarking large language models for genomic knowledge with GeneTuring.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Wenpin HouDepartment of Biostatistics, The Mailman School of Public Health, Columbia University, New York 10032, NY, USA.
Qi LiuDepartment of Biostatistics, The Mailman School of Public Health, Columbia University, New York 10032, NY, USA.
Huifang MaDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham 27705, NC, USA.
Yilong QuDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham 27705, NC, USA.
Zhicheng JiDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham 27705, NC, USA.

Funding

The Duke Senescent Cell Evaluations in Normal Tissues (SCENT) Mapping CenterU54AG075936 · NIA · DUKE UNIVERSITY · PI LEE, PATTY J · 2021 to 2025
$12.7M
Methods for inferring and analyzing gene regulatory networks using single-cell multiomics and spatial genomics dataR35GM150887 · NIGMS · DUKE UNIVERSITY · PI Wenpin Hou · 2023 to 2026
$1.6M
Computational methods for in situ spatial transcriptomicsR35GM154865 · NIGMS · DUKE UNIVERSITY · PI Zhicheng Ji · 2024 to 2026
$1.2M
Computational Methods for Inferring Single-cell DNA Methylation and its Spatial LandscapeR00HG011468 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOU, WENPIN · 2022 to 2024
$747k
NHGRI NIH HHS R00 HG011468NIA NIH HHS U54 AG075936NIGMS NIH HHS R35 GM150887NIGMS NIH HHS R35 GM154865
6 · The paper itself

Abstract

Image classification plays a pivotal role in analyzing biomedical images, serving as a cornerstone for both biological research and clinical diagnostics. It is demonstrated that large multimodal models (LMMs), like GPT-4, excel in one-shot learning, generalization, interpretability, and text-driven image classification across diverse biomedical tasks. These tasks include the classification of tissues, cell types, cellular states, and disease status. LMMs stand out from traditional single-modal classification approaches, which often require large training datasets and offer limited interpretability.

Indexed as

biomedical imageimage classificationlarge language modellarge multimodal modelmachine learning

Identifiers

PMID40836950
PMCPMC12360630

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.