ArticleJournal of cosmetic dermatology2025
Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Causal correlation between inflammatory cytokines and hypertrophic scar based on two-sample Mendelian randomization.Journal, genetic engineering & biotechnology · 2025Article
- Serum Vitamin D Levels and Its Relationship With Keloid, Acne or Hypertrophic Scar: A Two-Sample Mendelian Randomization Study.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies reported that patients with keloid, acne, or hypertrophic scar (HS) had lower serum vitamin D levels compared to healthy controls. Whereas, these works failed to verify their causal relationships. Hence, we performed a Mendelian randomization (MR) aimed to investigate the causal relationship between vitamin D and keloid, acne, or HS.
methodsUtilizing summary datasets from genome-wide association studies, we conducted a two-sample MR analysis to explore the causal relationship between vitamin D and keloid, acne, or HS. The inverse-variance weighted MR approach served as the primary analysis, with additional support from various sensitivity methods, including MR-Egger, weighted median, simple mode, weighted mode, and MR-PRESSO, to enhance the reliability of our findings.
resultsFrom our MR analyses, no causal relationships were found between vitamin D level and keloid (OR: 1.15, 95% CI: 0.853-1.16, p = 0.36), acne (OR: 0.94, 95% CI: 0.66-1.30, p = 0.65) or HS (OR: 1.20, 95% CI 0.79-1.82, p = 0.40) formation. After eliminating outliers through MR-PRESSO, no significant associations were found between serum vitamin D level and keloid, acne, as well as HS.
conclusionOur findings, backed by rigorous IV selection and consistent outcomes across various MR approaches, suggest no causal link between serum 25(OH)D levels and keloid, acne, or HS. While vitamin D is involved in wound healing, its connection to these conditions may not be straightforward, emphasizing the need for further research.
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Registered trials
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