Evidence map›Paper›PMID 40836810›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2025

Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.

Wanjun Gu, Elijah S Lawrence, A Mark Evans, Tatum S Simonson

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Pregnancy at high altitude: evolutionary and historical perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  4. Pregnancy at high altitude: the challenge of hypoxia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wanjun GuDepartment of Medicine, Division of Pulmonary, Crtiical Care, Sleep Medicine, and Physiology, University of California, San Diego, CA, USA.
Elijah S LawrenceDepartment of Medicine, Division of Pulmonary, Crtiical Care, Sleep Medicine, and Physiology, University of California, San Diego, CA, USA.
A Mark EvansInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.ORCID 0000-0002-4650-7208
Tatum S SimonsonDepartment of Medicine, Division of Pulmonary, Crtiical Care, Sleep Medicine, and Physiology, University of California, San Diego, CA, USA.ORCID 0000-0003-4062-2587

Funding

John B. West Endowed Chair in Respiratory PhysiologyNational Geographic SocietyNational Institutes of Health, National Heart, Lung, and Blood Institute
6 · The paper itself

Abstract

Advancements in genetic research have greatly enhanced our understanding of human adaptation to high-altitude environments through the identification of genetic markers linked to hypoxia tolerance. Our recent studies identify key genes associated with haematological and ventilatory traits in Andeans. Adaptive variation at

Indexed as

AcclimatizationAdaptation, PhysiologicalAltitudeBasic Helix-Loop-Helix ProteinsAMP-Activated Protein KinasesEndothelial PAS Domain-Containing Protein 1FemaleHumansHypoxiaPregnancyAMP-Activated Protein KinasesBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1adaptationaltitudehypoxiapregnancy

Identifiers

PMID40836810
PMCPMC12368535

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.