ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2025
The uteroplacental circulation at high altitude: adaptation and maladaptation.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Pregnancy at high altitude: evolutionary and historical perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Pregnancy at high altitude: the challenge of hypoxia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The greatest challenge of living at high altitude is hypoxia. Hypoxia imposes immense impacts on reproduction. Gestation at high altitude is associated with high incidence of fetal growth restriction (FGR) and pre-eclampsia owing to maladaptation of uteroplacental circulation/placenta insufficiency and oxygen delivery to the fetus. Both disorders have been replicated in animal models at low altitude by hypoxic exposure. Intriguingly, high-altitude natives such as Tibetans and Andeans are relatively protected from FGR. Hypoxia constitutes a severe insult to the uteroplacental circulation. In response to hypoxia, a range of dynamic responses occurs in uteroplacental cells/tissues. To offset detrimental effects imposed by hypoxia, uteroplacental cells/tissues also develop countermeasure mechanisms. The uteroplacental circulation adaptation to high altitude depends on whether a novel homeostasis is achieved.This article is part of the discussion meeting issue 'Pregnancy at high altitude: the challenge of hypoxia'.
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Registered trials
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