ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2025
Maternal body mass index is related to fetal uptake of glucose and oxygen via fetal insulin resistance rather than fetal glucose levels.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Pregnancy at high altitude: evolutionary and historical perspectives.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- Pregnancy at high altitude: the challenge of hypoxia.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
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7 authors.
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Abstract
Maternal obesity significantly impacts fetal growth and is linked to adverse pregnancy outcomes. However, the specific influence of maternal metabolic status on fetal metabolism and growth in healthy pregnancies is poorly understood. This study investigates the hypothesis that pre-pregnancy maternal body mass index (BMI) correlates with increased fetal insulin resistance, subsequently affecting fetal glucose and oxygen uptake-key determinants of growth. We examined 32 participants with healthy pregnancies, assessing pre-pregnancy BMI alongside blood gas analyses, umbilical glucose, insulin, lactate levels and Doppler blood flow in the umbilical vein. Our findings reveal a positive correlation between maternal BMI and fetal insulin resistance, indicated by the homeostatic model assessment for insulin resistance (HOMA-IR) (
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