Evidence map›Paper›PMID 40836713›Full record

SynthesisThoracic cancer2025

Rescue Surgery for Advanced Stage Lung Cancer: A Systematic Review.

Beatrice Leonardi, Gaetana Messina, Giuseppe Vicario, Davide Gerardo Pica, Vincenzo Di Filippo, Riccardo Vinciguerra, Francesca Capasso, Alessia Caputo, Noemi Maria Giorgiano, Anna D'Agostino and 12 more

Abstract readSystematic Review
In one paragraph

Synthesis in Thoracic cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Beatrice LeonardiThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0002-5595-6849
Gaetana MessinaThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0001-5129-7201
Giuseppe VicarioThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Davide Gerardo PicaThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0002-8203-6562
Vincenzo Di FilippoThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Riccardo VinciguerraThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0009-0001-1328-5928
Francesca CapassoThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alessia CaputoThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Noemi Maria GiorgianoThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0009-0006-4029-5837
Anna D'AgostinoThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Angela IovineThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alessia Angela GuarinoThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Martina RobustelliThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Carminia Maria Della CorteOncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Floriana MorgilloOncology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Elisa VarrialeOncology Unit, Buon Consiglio Fatebenefratelli Hospital, Naples, Italy.
Damiano CapaccioPneumology Unit, Eboli Hospital, Italy.
Antonio GrimaldiOncology Unit, A.O.R.N. San Pio, Benevento, Italy.
Renato FrancoPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0002-8340-3184
Stefano LucàPathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Giovanni VicidominiThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.
Alfonso FiorelliThoracic Surgery Unit, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID https://orcid.org/0000-0002-0628-613X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with advanced lung cancer are candidates for systemic therapies. In the context of improved tumor responses and prolonged survival periods, the treatment of tumor/therapy-related complications must be taken into account. Rescue surgery consists of a surgical resection without oncologic purpose but with the aim of controlling an acute and life-threatening complication. We evaluated the postoperative outcomes of patients with advanced stage lung cancer who underwent rescue surgery for tumor or therapy-related life-threatening complications. We conducted a systematic review of literature using PubMed, Scopus, Embase, and Google Scholar using following keywords: ("rescue surgery" or "salvage surgery" or "salvage lung resection") and ("lung cancer" or "non-small cell lung cancer" or "NSCLC" or "SCLC"). The primary outcome was overall survival. Secondary outcomes were the morbidity and mortality. Nine articles were included in our review for a total of 64 patients. The most common indications for rescue surgery were lung abscess, post-obstructive pneumonia, hemoptysis, and empyema. The lung resection consisted of lobectomy (n = 31, 48%), bilobectomy (n = 5, 8%), pneumonectomy (n = 11, 17%), sleeve pneumonectomy (n = 15, 23%), sleeve lobectomy (n = 1, 2%), and segmentectomy (n = 1, 2%). The mean overall survival was 12 months; the postoperative complication rate was 51%. No intraoperative deaths were observed. Rescue surgery is feasible for patients with advanced lung cancer and tumor/therapy-related life-threatening complications. Rescue surgery may allow access to ulterior systemic therapies; but the risk-benefit imbalance should always be taken into account, considering this as a last resort treatment.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsPneumonectomySalvage TherapyHumansNeoplasm StagingPostoperative Complications

Identifiers

PMID40836713
PMCPMC12368350

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.