Evidence map›Paper›PMID 40836499›Full record

ArticlePediatric blood & cancer2025

Pediatric and Young Adult Cancer Incidence in the United States During the COVID-19 Pandemic.

David A Siegel, Christine M Kava, Logan G Spector, Philip J Lupo, Eric B Durbin, Eric Tai, S Jane Henley

Abstract read
In one paragraph

Article in Pediatric blood & cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

David A SiegelDivision of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-1394-0782
Christine M KavaDivision of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0003-4634-3837
Logan G SpectorDivision of Epidemiology/Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.ORCID https://orcid.org/0000-0003-2516-0222
Philip J LupoBaylor College of Medicine, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-0978-5863
Eric B DurbinKentucky Cancer Registry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, USA.ORCID https://orcid.org/0000-0002-5600-7645
Eric TaiDivision of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0001-5184-9037
S Jane HenleyDivision of Cancer Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID https://orcid.org/0000-0002-2420-306X

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundCancer incidence decreased during the COVID-19 pandemic; this study describes cancer incidence changes for children, adolescents, and young adults during this period. We used US Cancer Statistics (USCS) to describe potential impacts of the pandemic on cancer incidence for persons 0-39 years.

methodsWe used data from USCS, covering 98% of the US population, to evaluate cancer case counts, incidence rates, and monthly counts; incidence rate ratios were calculated comparing year 2019 (baseline) to 2020 and 2021. We calculated trends using joinpoint regression for the period 2003-2021.

resultsComparing 2019 with 2020, cancer incidence decreased 5% (95% confidence interval [CI], 3%-7%) for ages 0-19 years and 7% (95% CI, 6%-8%) for ages 20-39. For ages 0-19, decreases were seen for thyroid cancer, melanoma, and nonmalignant central nervous system (CNS) neoplasms. For ages 20-39, decreases were seen for leukemias, lymphomas, CNS neoplasms, sarcomas, melanoma, and some carcinoma types. Decreases in 2020 were least pronounced for the distant stage at diagnosis. For ages 0-39, new diagnoses were lowest during March or April 2020 but returned to prepandemic levels during the second half of 2020. Decreases in 2021 were consistent with previously decreasing trends for many cancer types.

conclusionsCancer rate decreases were largest for young adults (vs. children) and were significant for some cancer types. These findings might help assess the impacts of the COVID-19 pandemic, inform investigations into potential causes of these decreases, and guide responses to future public health crises.

Indexed as

COVID-19NeoplasmsSARS-CoV-2AdolescentAdultChildChild, PreschoolFemaleHumansIncidenceInfantInfant, NewbornMalePandemicsUnited StatesYoung AdultcancerCOVID‐19incidencepediatricregistriesyoung adult

Identifiers

PMID40836499
PMCPMC12416144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.