SynthesisAnnals of medicine2025
A systematic review of the association between ultrasound-detected features and laboratory inflammatory biomarkers in hand osteoarthritis.
Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hand Osteoarthritis in the Elderly: The Prevalence of Articular Cartilage Defects in Radiographically Normal and Affected Joints.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo systematically review observational studies for the relationship between ultrasound (US)-detected features and laboratory inflammatory biomarkers in hand osteoarthritis (OA).
methodsA systematic literature search was performed in MEDLINE, EMBASE, CINAHL, and Web of Science from their inception to June 2025 to identify relevant observational studies. Study quality was evaluated using the Newcastle-Ottawa Scale (NOS), with two independent reviewers validating the papers. Correlation coefficients and corresponding confidence intervals and P values between US-detected features and biomarkers were extracted and analysed.
resultsOut of 5,128 citations, four studies (546 participants, 91.75% female, mean age 56.1-66.3 years) scored >5 on the NOS. Significant correlations (
conclusionThese findings highlight a critical gap in research linking US-detected features and serum inflammatory markers in hand OA. While some evidence suggests that US-detected GSS may reflect subclinical inflammation, particularly in erosive hand OA, inconsistent results across studies underscore the need for larger, standardised research to support phenotyping and inform targeted diagnostic and therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.