ArticleBMC oral health2025
The toxic effect of titanium dioxide nanoparticles on rat submandibular salivary glands and the protective role of vitamin E.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Protective Effects of Virgin Olive Oil Against Titanium Dioxide Nanoparticle-Induced Hepato-Renal Toxicity: Evidence from Oxidative Stress Biomarkers and Restoration of Antioxidant Enzyme Activities.Biological trace element research · 2026Article
- Histopathological effect of hypervitaminosis DBMC oral health · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
backgroundTo assess the impact of titanium dioxide nanoparticles (TiO
methodsThirty adult male albino rats were randomly divided into 3 groups: Negative control received olive oil for 3 weeks; Study I received olive oil for 1 week, then daily oral administration of 300 mg/kg TiO
resultsSerum levels of both MDA and IL-1β were significantly greater in study I than in control and study II groups. Histologic examination revealed structural changes in serous acini and ducts of study I, with great preservation of the normal appearance of the acini and ducts in study II. Histomorphometry revealed a significant difference between control and study I, with no significant difference from that in study II. TEM revealed multiple ultrastructural changes in acinar cells and ducts of study I compared with those of study II, which maintained their normal features.
conclusionsVitamin E plays crucial antioxidant and anti-inflammatory roles in counteracting the cytotoxic effects of TiO
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Registered trials
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