ArticleEuropean journal of medical research2025
Quercetin improves myocardial ischemia-reperfusion injury by regulating macrophage M2 polarization through Bcl-2/Beclin-1 complex.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Isopsoralen Promotes Mandibular Fracture Healing by Regulating Autophagy.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Dietary Polyphenols in Aging: A Systems-Level Perspective on Mitochondrial Quality Control and Microbiome Interactions.International journal of molecular sciences · 2026Review
- Chronic quercetin supplementation modulates cardiac function and signaling pathways in aged male Wistar rat hearts subjected to ischemia-reperfusion.Frontiers in cardiovascular medicine · 2026Article
- Macrophage polarization in acute myocardial infarction: multidimensional regulation and emerging therapeutic opportunities.Frontiers in immunology · 2025Review
- Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis.Dose-response : a publication of International Hormesis SocietyArticle
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Abstract
backgroundMyocardial ischemia-reperfusion injury (MIRI) is a common pathological phenomenon during the treatment of acute myocardial infarction. Recent studies suggest that macrophage polarization plays a crucial role in MIRI progression. However, whether quercetin mitigates MIRI by modulating macrophage polarization and the underlying molecular mechanisms remain unclear.
methodsThe protective effects of quercetin against MIRI were assessed using TTC-Evans blue staining, echocardiography, and myocardial enzyme assays. Histological changes, including myocardial fibrosis, were evaluated via HE and Masson staining. Western blot, qPCR, and immunofluorescence were performed to analyze macrophage M1/M2 polarization. Additionally, co-immunoprecipitation (Co-IP) assays were conducted to determine whether quercetin regulates M2 polarization through autophagy modulation.
resultsQuercetin significantly reduced infarct size, improved cardiac function, and alleviated inflammation and myocardial fibrosis in a dose-dependent manner. Western blot and immunofluorescence analyses showed that quercetin downregulated M1 markers while upregulating M2 markers and enhancing IL-10 secretion. In vitro experiments further confirmed that quercetin promoted M2 macrophage polarization under H/R conditions, thereby attenuating cardiomyocyte injury through a paracrine mechanism. Mechanistically, quercetin facilitated autophagic flux by reducing the binding affinity between Bcl-2 and Beclin-1, leading to enhanced M2 macrophage polarization, an effect partially reversed by 3-MA.
conclusionThis study provides the first evidence that quercetin exerts cardioprotective effects in MIRI by promoting M2 macrophage polarization. Furthermore, it elucidates a novel molecular mechanism in which quercetin regulates autophagy to drive M2 polarization, offering experimental support for quercetin as a potential therapeutic strategy for MIRI.
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