Evidence map›Paper›PMID 40836304›Full record

ArticleMolecular brain2025

Generation of a new Slc20a2 knockout mouse line as in vivo model for primary brain calcification.

Hisaka Kurita, Hiroki Kitaura, Kazuya Nishii, Tomohiko Masaka, Kazuki Ohuchi, Masatoshi Inden, Akiyoshi Kakita, Masatake Osawa, Isao Hozumi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hisaka Kurita *Laboratory of Medical Therapeutics and Molecular Therapeutics, Department Biomedical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu City, 501-1196, Gifu, Japan.
Hiroki Kitaura *Department of Pathology, Brain Research Institute, Niigata University, 1- 757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Kazuya NishiiLaboratory of Medical Therapeutics and Molecular Therapeutics, Department Biomedical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu City, 501-1196, Gifu, Japan.
Tomohiko MasakaLaboratory of Medical Therapeutics and Molecular Therapeutics, Department Biomedical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu City, 501-1196, Gifu, Japan.
Kazuki OhuchiLaboratory of Medical Therapeutics and Molecular Therapeutics, Department Biomedical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu City, 501-1196, Gifu, Japan.
Masatoshi IndenLaboratory of Medical Therapeutics and Molecular Therapeutics, Department Biomedical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu City, 501-1196, Gifu, Japan.
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, 1- 757 Asahimachi, Chuo-ku, Niigata, 951-8585, Japan.
Masatake OsawaDepartment of Regenerative Medicine and Applied Medical Sciences, Graduate School of Medicine, Gifu University, Gifu City, Gifu, Japan.
Isao HozumiLaboratory of Medical Therapeutics and Molecular Therapeutics, Department Biomedical Pharmaceutics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu City, 501-1196, Gifu, Japan. hozumi@gifu-pu.ac.jp.

Funding

Japan Agency for Medical Research and Development 20ek0109313h003Japan Agency for Medical Research and Development 20ek0109313s0103Japan Agency for Medical Research and Development 20ek0109313s0203the Ministry of Education, Culture, Sports, Science and Technology of Japan 17H04198
6 · The paper itself

Abstract

Primary brain calcification (PBC) is a neurodegenerative disease that causes bilateral ectopic calcification in the brain. In this study, using newly generated Slc20a2 knockout (Slc20a2

Indexed as

BrainCalcinosisSodium-Phosphate Cotransporter Proteins, Type IIIAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutSlc20a2 protein, mouseSodium-Phosphate Cotransporter Proteins, Type IIIIn vivo modelPrimary brain calcificationSLC20A2

Identifiers

PMID40836304
PMCPMC12369223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.