Observational studyBMC infectious diseases2025
Incidence and risk factors of resistant Pseudomonas aeruginosa infections: a multicenter study in Lebanese tertiary hospitals.
Observational study in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Detection of carbapenem resistance mechanisms in difficult-to-treat Pseudomonas aeruginosa clinical isolates from a tertiary care hospital in Egypt.BMC microbiology · 2026Article
- Beyond Colonization: Dynamic Risk Stratification and Clinical Decision-Making for MDR Gram-Negative Infections in Critically Ill Patients.Biomedicines · 2026Review
- A Flexible Ionically Conductive Biopolymer Hydrogel Interface for Physiological Signal Acquisition: A Chitosan-Glycerol-PVA Composite.Materials (Basel, Switzerland) · 2026Article
- Epidemiological characteristics and temporal trends of major multidrug-resistant bacteria in a tertiary maternal and child health hospital from 2021 to 2024.BMC infectious diseases · 2026Article
- Genetic Determinants Linked to MDR/XDR inPathogens (Basel, Switzerland) · 2026Article
- Epidemiology, Antimicrobial Resistance, and Seasonal Dynamics of Respiratory Bacterial Pathogens in a Saudi Tertiary Care Hospital (2023-2025).Infection and drug resistance · 2026Article
- Clinical gradient and predictors for stepwise resistance escalation of carbapenem-susceptible, carbapenem-resistant, and difficult-to-treat resistantFrontiers in cellular and infection microbiology · 2026Article
- Bacterial pathogen spectrum and antimicrobial resistance in positive pus cultures from hospitalized patients at a maternal and child healthcare specialty hospital in Shenzhen, China, 2021-2025.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
backgroundThe emergence of difficult-to-treat resistant (DTR) Pseudomonas aeruginosa infections poses a significant clinical challenge, characterized by limited treatment options, poor outcomes, and increased morbidity and mortality. DTR P. aeruginosa isolates exhibit resistance to all first-line antibiotics, necessitating the use of less effective or more toxic alternatives. This study estimated the incidence of DTR P. aeruginosa infections in Lebanon and identified the associated risk factors.
methodsThis retrospective observational study was conducted across four tertiary care centers in Beirut, Lebanon, over a three-year period from 2021 to 2023. Univariate and multivariate logistic regression analyses were performed to identify significant predictors associated with DTR P. aeruginosa infections.
resultsA total of 2,639 cases with positive P. aeruginosa isolates were initially screened, with 477 cases meeting the inclusion criteria for analysis. The mean age of the patients was 66.3 ± 17.8 years, and the mean Charlson Comorbidity Index was 4.46 ± 2.43. Nearly half of the infections were nosocomial (47.6%). The most common primary site of infection was the respiratory tract (38.8%), followed by skin and soft tissue (32.7%). The incidence of DTR P. aeruginosa was 15.3%, and the incidence of carbapenem-resistant P. aeruginosa (CRPA) was 29.9%. Binary logistic regression identified three main risk factors for DTR P. aeruginosa infection acquisition: infections occurring during the winter season (adjusted odds ratio [AOR] = 6.08, 95% CI = 2.75–16.13, P < 0.01), intensive care unit stay (AOR = 2.52, 95% CI = 1.28–4.98, P < 0.01), and infections originating from the respiratory tract (AOR = 2.49, 95% CI = 1.04–5.97, P = 0.04).
conclusionsThe incidence of DTR P. aeruginosa in Lebanese hospitals is substantial compared to global rates and poses a significant challenge to effective treatment. Urgent measures are required to prevent and mitigate the spread of DTR P. aeruginosa infections. Hospital-based antimicrobial stewardship and infection control programs need to be reinforced, and community-based initiatives should be implemented at the national level. Efforts to combat antimicrobial resistance must be supported by ongoing nationwide annual surveillance.
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