Evidence map›Paper›PMID 40836217›Full record

SynthesisBMC gastroenterology2025

The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis.

Tingting Yuan, Guiqing Jia, Wei Cao, Haixia Chen, Jing Zhang, Min Liu, Wenwen Gan, Yanli Zeng

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tingting Yuan *Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Guiqing Jia *Department of Gastrointestinal Surgery, Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Wei CaoDepartment of Hepatobiliary and Pancreatic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Haixia ChenDepartment of Gastrointestinal Surgery, Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Jing ZhangDepartment of Thoracic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Min LiuDepartment of Anesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Wenwen GanDepartment of Gastrointestinal Surgery, Sichuan Provincial People's Hospital,University of Electronic Science and Technology of China, Chengdu, Sichuan, 610072, China.
Yanli ZengCollege of Nursing, Chengdu University of Traditional Chinese Medicine, No.1166 Liutai Road, Wenjiang District, Chengdu, Sichuan, 611137, China. zengyanli@cdutcm.edu.cn.

Funding

Foundation of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital 2021LY14Sichuan Provincial Health Foundation Chuanganyan 2022-217
6 · The paper itself

Abstract

This study aims to evaluate the association between IDO index and the prognosis of colorectal cancer (CRC). We searched databases such as PubMed, to collect relevant English studies on the association between IDO level and the prognosis of CRC published before October 10, 2024. This meta-analysis included 11 studies involving 2068 patients. The results showed that IDO levels were not significantly correlated with OS in CRC patients (HR0.85, 95%CI 0.54-1.33, P = 0.488), but elevated IDO was associated with reduced disease-free survival (DFS) in CRC patients (HR 0.61, 95%CI 0.38-0.99, P = 0.044).Elevated IDO was significantly associated with the incidence of liver metastasis (HR 4.66, 95%CI 1.72-12.64, P = 0.003) and lymphatic infiltration (HR 2.75, 95%CI 1.52-4.97, P < 0.001) in CRC patients. In conclusion, high expression of IDO is significantly associated with DFS, liver metastasis and lymphatic infiltration in CRC patients, and may serve as a biomarker and therapeutic target for DFS, liver metastasis, and lymphatic metastasis in CRC.

Indexed as

Colorectal NeoplasmsIndoleamine-Pyrrole 2,3,-DioxygenaseBiomarkers, TumorDisease-Free SurvivalHumansLiver NeoplasmsLymphatic MetastasisPrognosisBiomarkers, TumorIndoleamine-Pyrrole 2,3,-Dioxygenase3-dioxygenaseColorectal cancerTryptophan 2

Identifiers

PMID40836217
PMCPMC12366024

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.