Evidence map›Paper›PMID 40836188›Full record

ArticleDrug delivery and translational research2025

Improved cognition and memory via PLGA nanoparticle-mediated delivery of curcumin and piperine in an in vivo Alzheimer's disease model.

Zhi Xin Phuna, Shantini Vijayabalan, Bibhu Prasad Panda, Naveen Kumar Hawala Shivashekaregowda, Mohd Farooq Shaikh, Priya Madhavan

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Article in Drug delivery and translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhi Xin PhunaSchool of Medicine, Faculty of Health & Medical Sciences, Taylor's University, No.1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia.
Shantini VijayabalanDepartment of Pharmaceutical Technology, School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University, No.1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia.
Bibhu Prasad PandaDepartment of Pharmaceutical Technology, School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University, No.1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia.
Naveen Kumar Hawala ShivashekaregowdaDepartment of Pharmaceutical Chemistry, School of Pharmacy, Faculty of Health & Medical Sciences, Taylor's University, No.1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia.
Mohd Farooq ShaikhNeuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia.
Priya MadhavanSchool of Medicine, Faculty of Health & Medical Sciences, Taylor's University, No.1, Jalan Taylor's, 47500, Subang Jaya, Selangor, Malaysia. Priya.Madhavan@taylors.edu.my.ORCID 0000-0001-6714-1279

Funding

Taylor's University TUFR/2017/002/04
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that causes dementia, impaired cognitive function, and disorientation. Studies have revealed that curcumin and piperine were found to be neuroprotective for patients with dementia. Nevertheless, both compounds are known for their poor solubility. To address issues related to poor bioavailability, polymeric nanoparticles loaded with curcumin and piperine, in combination, were fabricated and characterized through physicochemical, surface morphology, drug-excipient compatibility, and bioavailability studies. The nanoparticle with the highest bioavailability was selected for pharmacokinetics and pharmacodynamics studies. Optimized Poly (D, L-lactide-co-glycolide) nanoparticles loaded with curcumin and piperine, which we refer to as functional nanoparticles (FNP), were successfully developed using the emulsion diffusion-high-pressure homogenization-solvent evaporation (EHS) technique with Poloxamer 188 as the stabilizer. Among nine formulations obtained, FNP1 had a particle size of 116.6 ± 2.13 nm and a zeta potential of -27.9 ± 1.51 mV. Saturation solubility and in vitro drug release studies demonstrated an enhanced solubility of curcumin and piperine in FNP1 compared to the pure compounds. Oral administration of FNP1 in a streptozotocin (STZ)-induced AD rat model resulted in significant improvement of spatial memory, as demonstrated by both the Morris Water Maze and Passive Avoidance tests. Further histology studies, which involved staining the cortex and hippocampus regions, revealed a significantly reduced number of pyramidal cells with extensive nuclear pyknosis and degeneration, a finding previously observed in untreated STZ-induced AD rats. This study concluded that the polymeric nanoparticle developed, FNP1, had successfully improved the solubility and bioavailability of curcumin and piperine, thereby enhancing cognitive and memory impairment in STZ-induced AD rats.

Indexed as

AlkaloidsAlzheimer DiseaseBenzodioxolesCognitionCurcuminMemoryNanoparticlesNeuroprotective AgentsPiperidinesPolyglycolic AcidPolyunsaturated AlkamidesAnimalsBiological AvailabilityDisease Models, AnimalDrug CarriersDrug LiberationAlkaloidsBenzodioxolesCurcuminDrug CarriersNeuroprotective AgentsPiperidinespiperinePolyglycolic AcidPolylactic Acid-Polyglycolic Acid CopolymerPolyunsaturated AlkamidesAlzheimer’s diseaseCognitionCurcuminMemoryNanoparticlePiperine

Identifiers

PMID40836188

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.