Evidence map›Paper›PMID 40836182›Full record

ReviewAAPS PharmSciTech2025

Stimuli-responsive Hydrogels for Targeted Antibiotic Delivery in Bone Tissue Engineering.

Jayendra Kumar, Tolepbergenova M, Abdugani Musayev, Aizhan Danyshbayeva, Lazzat Begimbekova, Hitesh Kumar, Terlikbayeva Gulnar, Pawan Kumar, Shamim Shamim

Abstract readReview
PubMed Publisher
In one paragraph

Review in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jayendra KumarDepartment of Pharmaceutical Chemistry, SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology, Uttar Pradesh, Delhi-NCR Campus, Modinagar, Ghaziabad, 201204, India.ORCID http://orcid.org/0000-0002-6651-6371
Tolepbergenova MDepartment of Pathological Physiology, Kazakh National Medical University, Almaty, 050000, Kazakhstan.ORCID http://orcid.org/0009-0009-7425-5333
Abdugani MusayevDepartment of Pathological Physiology, Kazakh National Medical University, Almaty, 050000, Kazakhstan.ORCID http://orcid.org/0000-0001-7782-6255
Aizhan DanyshbayevaDepartment of Pathological Physiology, Kazakh National Medical University, Almaty, 050000, Kazakhstan.ORCID http://orcid.org/0000-0003-1039-3891
Lazzat BegimbekovaInternational Kazakh-Turkish University (Ahmet Yassawi University), Turkistan, 161200, Kazakhstan.ORCID http://orcid.org/0000-0001-8666-8711
Hitesh KumarSchool of Pharmaceutical Sciences, Om Sterling Global University, Hisar, 125001, Haryana, India.ORCID http://orcid.org/0000-0002-9611-3127
Terlikbayeva GulnarDepartment of Pathological Physiology, Kazakh National Medical University, Almaty, 050000, Kazakhstan.ORCID http://orcid.org/0009-0004-5368-2129
Pawan KumarDepartment of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, 151001, Punjab, India. pawankamiya@yahoo.in.ORCID http://orcid.org/0000-0001-6549-9779
Shamim ShamimDepartment of Pharmacy, IIMT College of Medical Sciences, IIMT University, Ganga Nagar, Meerut, 250001, Uttar Pradesh, India.ORCID http://orcid.org/0009-0005-6103-1243

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue engineering (BTE) faces critical challenges in managing infections such as osteomyelitis, which complicate healing and compromise implant success. Conventional antibiotic therapies often fail to achieve effective localized drug concentrations without systemic toxicity. Stimuli-responsive hydrogels have emerged as a transformative solution, offering spatiotemporally controlled, on-demand antibiotic release triggered by environmental cues such as pH, temperature, enzymatic activity, and redox conditions. This review comprehensively analyzes hydrogel classification, design strategies, and their integration within BTE scaffolds. It highlights the synergistic benefits of smart hydrogels in supporting osteogenic differentiation, enhancing vascularization, and combating infection. Key antibiotic delivery mechanisms-from enzyme-sensitive nanocomposites to dual-stimuli systems-are critically examined alongside their pharmacokinetic advantages and limitations. The article also discusses current translational barriers, including mechanical stability, biocompatibility, and regulatory hurdles, while presenting future directions such as biosensing-enabled, 3D-bioprinted, and AI-assisted platforms. Overall, stimuli-responsive hydrogels represent a promising paradigm in precision antibiotic delivery and regenerative bone therapy.

Indexed as

Anti-Bacterial AgentsBone and BonesDrug Delivery SystemsHydrogelsTissue EngineeringAnimalsHumansHydrogen-Ion ConcentrationOsteogenesisTissue ScaffoldsAnti-Bacterial AgentsHydrogelsbioactive scaffoldsbone tissue engineeringenvironment-sensitive drug releaselocalized antibiotic deliverysmart biomaterialsstimuli-responsive hydrogels

Identifiers

PMID40836182

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.