ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Delayed otorrhagia due to Radiation-induced external carotid artery pseudoaneurysm complicated by Temporal bone osteoradionecrosis in nasopharyngeal carcinoma: A case report and literature review.
Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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4 authors.
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Abstract
backgroundPseudoaneurysms following radiotherapy for nasopharyngeal carcinoma (NPC) commonly involve the internal carotid artery (ICA) with epistaxis. External carotid artery (ECA) pseudoaneurysm complicated by temporal bone osteoradionecrosis (ORN) presenting with otorrhagia represents an exceptionally rare, life-threatening complication.
methodsWe reported a case of delayed otorrhagia due to superficial temporal artery pseudoaneurysm complicated by temporal bone ORN and conducted a literature review of radiation-induced carotid pseudoaneurysms in NPC patients. A PubMed search (2004-2025) was conducted with key words "nasopharyngeal carcinoma", "pseudoaneurysm", "carotid artery" and "radiotherapy" to identify similar cases.
resultsWe identified 16 cases of radiation-induced carotid artery pseudoaneurysms in NPC patients, with eight cases demonstrating skull base ORN and two originating from ECA, none showing tumor recurrence. Our case was managed through CT angiogram followed by selective ECA digital subtraction angiography with successful coil embolization.
conclusionThis first-reported case of ECA branch pseudoaneurysm secondary to temporal bone ORN establishes that ORN and soft tissue necrosis predispose to pseudoaneurysm formation. The 19-year latency period highlights the necessity for long-term surveillance in high-risk patients. First-line CT angiography should mandate comprehensive ECA evaluation. Sentinel bleeding episodes with soft tissue necrosis warrant vascular assessment to mitigate pseudoaneurysm rupture risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.