Evidence map›Paper›PMID 40836125›Full record

ArticleNature aging2025

Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength.

Peter Vrtačnik, Lara G Merino, Santhilal Subhash, Hafdís T Helgadóttir, Matthieu Bardin, Fabiana Stefani, Depin Wang, Ping Chen, Irene Franco, Gwladys Revêchon and 1 more

Abstract read
In one paragraph

Article in Nature aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Senescent-Like Myofibers Contribute to Anti-Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peter Vrtačnik *Department of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.
Lara G Merino *Department of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-7208-953X
Santhilal SubhashDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-0077-4597
Hafdís T HelgadóttirDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0003-4352-152X
Matthieu BardinDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0001-9755-8841
Fabiana StefaniDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0009-0008-8933-0773
Depin WangResearch Program of Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Ping ChenResearch Program of Stem Cells and Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Irene FrancoDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden.ORCID http://orcid.org/0000-0002-4272-239X
Gwladys RevêchonDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden. gwladys.revechon@ki.se.ORCID http://orcid.org/0000-0002-4824-6793
Maria ErikssonDepartment of Medicine, Huddinge, Karolinska Institutet, Huddinge, Sweden. maria.eriksson.2@ki.se.ORCID http://orcid.org/0000-0003-3233-2862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is associated with a progressive decline in tissue function and regenerative capacity, partly due to genomic instability, one of the hallmarks of aging

Indexed as

AgingMuscle, SkeletalMuscle StrengthMutationRegenerationAnimalsDNA DamageGenomic InstabilityMaleMiceMutS Homolog 2 ProteinMsh2 protein, mouseMutS Homolog 2 Protein

Identifiers

PMID40836125
PMCPMC12443595

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.