Evidence map›Paper›PMID 40836102›Full record

ArticleCardiovascular and interventional radiology2025

Comparison of Dosimetry Models and Dose Thresholds for Predicting Pathologic Response to Yttrium-90 Radioembolization with Glass Microspheres.

Kurt T Pianka, Mark Barahman, Jeet Minocha, Jonas W Redmond, Gabriel T Schnickel, Venkatesh Krishnasamy, Steven C Rose, Kathryn J Fowler, Zachary T Berman

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kurt T PiankaSchool of Medicine, University of California San Diego, La Jolla, CA, USA.
Mark BarahmanDepartment of Radiology, University of California San Diego, San Diego, CA, USA.
Jeet MinochaDepartment of Radiology, University of California San Diego, San Diego, CA, USA.
Jonas W RedmondDepartment of Radiology, University of California San Diego, San Diego, CA, USA.
Gabriel T SchnickelDepartment of Surgery, University of California San Diego, La Jolla, CA, USA.
Venkatesh KrishnasamyDepartment of Radiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Steven C RoseDepartment of Radiology, University of California San Diego, San Diego, CA, USA.
Kathryn J FowlerDepartment of Radiology, Scripps Green Hospital, La Jolla, CA, USA.
Zachary T BermanDepartment of Radiology, University of California San Diego, San Diego, CA, USA. zberman@health.ucsd.edu.ORCID http://orcid.org/0000-0002-8651-9772

Funding

Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
NIBIB NIH HHS T32 EB005970
6 · The paper itself

Abstract

purposeThis study evaluated pathologic response to ablative transarterial radioembolization (TARE) and compared single-compartment, mean tumor dose, and voxel-based dosimetry thresholds for hepatocellular carcinoma (HCC). MATERIALS AND

methodsThis is a retrospective, single-center study which included consecutive patients treated with glass microsphere TARE for a previously untreated HCC followed by liver transplantation between January 2015 - December 2024. A complete response (CR) was assigned if explant pathology showed complete pathologic necrosis (CPN) and if the patient had not undergone further treatments to the tumor. The standard single-compartment, dual-compartment mean tumor, and voxel-based doses were compared for patients with CR and without.

resultsOf the forty-three patients included, 29 had a CR. The only single-compartment dose threshold significantly associated with CR was ≥ 400 Gy, with a positive predictive value (PPV) of 77%. Mean tumor dose thresholds of ≥ 300 and ≥ 400 Gy were associated with CR (PPV 75 and 76%, respectively). The highest PPV for CR observed was for the voxel-based dose threshold of D95 ≥ 500 Gy, at 88%. Single-compartment, dual-compartment mean tumor, and D95 doses were all significantly associated with the likelihood of CR in separate multivariable logistic regression analyses. The incidence of AEs did not vary significantly based on the tested dose thresholds.

conclusionIncreasing the single- and dual-compartment dose thresholds beyond ≥ 400 Gy did not result in significant associations with CR nor improved PPV. In contrast, D95 ≥ 500 Gy was significantly associated with CR with the highest observed PPV. LEVEL OF EVIDENCE: Level 3, Local Non-random Sample.

Indexed as

Carcinoma, HepatocellularEmbolization, TherapeuticLiver NeoplasmsYttrium RadioisotopesAgedFemaleGlassHumansMaleMicrospheresMiddle AgedRadiometryRadiopharmaceuticalsRadiotherapy DosageRetrospective StudiesTreatment OutcomeRadiopharmaceuticalsYttrium-90Yttrium RadioisotopesDosimetryHepatocellular carcinomaTransarterial radioembolization

Identifiers

PMID40836102
PMCPMC13065348

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.