ArticleNature2025
TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Epigenetic signatures mark early peripheral human B lineage bifurcation and differential transcriptional profiles in mature populations.Nature communications · 2026Article
- Autoreactive antibody production by intrarenal B cells in mouse kidney allograft rejection.bioRxiv : the preprint server for biology · 2026Article
- Article
- Molecular Pathogenesis and Therapeutic Response of Diffuse Large B Cell Lymphoma Genetic Subtypes.Annual review of cancer biology · 2026Article
- Do human B-1 lymphocytes truly exist?Frontiers in immunology · 2026Review
- The trinity of T cell engagement: navigating the molecular and clinical landscape of CAR-T, TILs, and TCEs in the war against cancer.Frontiers in immunology · 2026Review
- The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics.PloS one · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
34 authors.
Qian ShenFrancis Crick Institute, London, UK. qian.shen@crick.ac.uk.ORCID 0000-0003-1899-6937
Hao Wang *Francis Crick Institute, London, UK.
Jonathan A Roco *Francis Crick Institute, London, UK.
Xiangpeng Meng *Division of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0003-3447-0871
Marita BosticardoLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Marie HodgesSchool of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK.
Michael BattagliaDepartment of Biochemistry, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0003-4809-7991
Zhi-Ping FengANU Bioinformatics Consultancy, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0002-6627-5934
Benjamin James TalksBiosciences Institute, William Leech Building, Newcastle University, Newcastle Upon Tyne, UK.ORCID 0000-0003-4896-2324
Jason PowellTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Vijaya Baskar Mahalingam ShanmugiahWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Julia ChuCAMS Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-4956-2189
Najib M RahmanOxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.ORCID 0000-0003-1195-1680
Alguili ElsheikhOxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Probir ChakravartyFrancis Crick Institute, London, UK.
Amalie GrenovFrancis Crick Institute, London, UK.ORCID 0000-0001-6310-565X
Max EmmerichFrancis Crick Institute, London, UK.ORCID 0000-0002-2026-974X
Ottavia M DelmonteLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Alexandra F FreemanLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.
Michael D KellerDivision of Allergy and Immunology, Children's National Hospital, Washington, DC, USA.
Brahim BelaidDepartment of Medical Immunology, Beni Messous University Hospital Center, Faculty of Pharmacy, University of Algiers, Algiers, Algeria.
Ilenia PapaFrancis Crick Institute, London, UK.ORCID 0000-0003-3167-7623
James C LeeFrancis Crick Institute, London, UK.ORCID 0000-0001-5711-9385
Pablo F CañeteFrazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Paula Gonzalez-FigueroaFrancis Crick Institute, London, UK.ORCID 0000-0001-8270-552X
Yaoyuan ZhangDivision of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.
Hai-Hui XueCentre for Discovery and Innovation, Hackensack University Medical Center, Nutley, NJ, USA.ORCID 0000-0002-9163-7669
Samra TurajlicFrancis Crick Institute, London, UK.ORCID 0000-0001-8846-136X
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-8335-0262
Muzlifah HaniffaWellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.ORCID 0000-0002-3927-2084
Lee Ann Garrett-SinhaDepartment of Biochemistry, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-7806-4352
Helen M ParrySchool of Infection, Inflammation and Immunology, University of Birmingham, Birmingham, UK.
Nikolaos I KanellakisCAMS Oxford Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-0065-2282
Carola G VinuesaFrancis Crick Institute, London, UK. carola.vinuesa@crick.ac.uk.ORCID 0000-0001-9799-0298
Funding
Wellcome Trust CC2228
Abstract
B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial
Indexed as
B-Lymphocyte SubsetsHepatocyte Nuclear Factor 1-alphaHomeostasisLymphoid Enhancer-Binding Factor 1AnimalsCell ProliferationFemaleHumansInterleukin-10MaleMiceMice, Inbred C57BLProto-Oncogene Proteins c-mycSpleenHepatocyte Nuclear Factor 1-alphaHnf1a protein, mouseInterleukin-10Lef1 protein, mouseLymphoid Enhancer-Binding Factor 1Proto-Oncogene Proteins c-myc
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.