Evidence map›Paper›PMID 40836097›Full record

ArticleNature2025

SLC45A4 is a pain gene encoding a neuronal polyamine transporter.

Steven J Middleton, Sigurbjörn Markússon, Mikael Åkerlund, Justin C Deme, Mandy Tseng, Wenqianglong Li, Sana R Zuberi, Gabriel Kuteyi, Peter Sarkies, Georgios Baskozos and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. iScience · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Dyslipidemia is a metabolic hallmark of acute pain in sickle cell disease.medRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Polyamine Metabolism in Brain Health and Disease.Neuropharmacology and therapy · 2026
    Article
  8. Article
  9. Article
  10. Polyamine homeostasisbioRxiv : the preprint server for biology · 2025
    Article
  11. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors.

Steven J Middleton *Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.ORCID 0000-0002-0708-7335
Sigurbjörn Markússon *Department of Biochemistry, University of Oxford, Oxford, UK.
Mikael ÅkerlundDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.
Justin C DemeCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0001-8811-9871
Mandy TsengNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.
Wenqianglong LiNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.
Sana R ZuberiNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.
Gabriel KuteyiDepartment of Biochemistry, University of Oxford, Oxford, UK.
Peter SarkiesDepartment of Biochemistry, University of Oxford, Oxford, UK.
Georgios BaskozosNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.ORCID 0000-0001-9237-5878
Jimena Perez-SanchezNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.ORCID 0000-0002-4967-5418
Adham FarahNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.
Harry L HébertChronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Sylvanus ToikumoMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.
Zhanru YuChinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.
Susan MaxwellNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.ORCID 0009-0009-6514-149X
Yin Y DongNuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK.
Benedikt M KesslerChinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.ORCID 0000-0002-8160-2446
Henry R KranzlerMental Illness Research, Education and Clinical Center, Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID 0000-0002-1018-0450
John E LinleyNeuroscience, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Blair H SmithChronic Pain Research Group, Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.ORCID 0000-0002-5362-9430
Susan M LeaCenter for Structural Biology, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID 0000-0001-9287-8053
Joanne L ParkerDepartment of Biochemistry, University of Oxford, Oxford, UK.ORCID 0000-0003-2964-2720
Valeriya LyssenkoDepartment of Clinical Sciences, Lund University Diabetes Centre, Lund University, Lund, Sweden.
Simon Newstead *Department of Biochemistry, University of Oxford, Oxford, UK. Simon.newstead@bioch.ox.ac.uk.ORCID 0000-0001-7432-2270
David L Bennett *Nuffield Department of Clinical Neurosciences, The University of Oxford, Oxford, UK. David.bennett@ndcn.ox.ac.uk.ORCID 0000-0002-7996-2696

Funding

Leveraging GWAS Findings to Map Variants and Identify Novel Effector Genes for Alcohol-Related TraitsR01AA030056 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI Struan F A Grant, MATTHEW S KAYSER · 2023 to 2026
$2.5M
BLRD VA I01 BX004820NIAAA NIH HHS R01 AA030056Wellcome Trust
6 · The paper itself

Abstract

Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy

Indexed as

Chronic PainMembrane Transport ProteinsPainPolyaminesSymportersAnimalsCell MembraneCryoelectron MicroscopyFemaleGanglia, SpinalGenome-Wide Association StudyHumansMaleMiceNeuronsNociceptorsMembrane Transport ProteinsPolyaminesSLC45A4 protein, mouseSymporters

Identifiers

PMID40836097
PMCPMC12507699

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.