Evidence map›Paper›PMID 40836081›Full record

ArticleNature2025

Axonal injury is a targetable driver of glioblastoma progression.

Melanie Clements, Wenhao Tang, Zan Florjanic Baronik, Holly Simpson Ragdale, Roger Oria, Dimitrios Volteras, Ian J White, Gordon Beattie, Imran Uddin, Tchern Lenn and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
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  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Glioma neuron symbiosis: a hypothesis.Frontiers in neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Melanie Clements *Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK.ORCID 0000-0001-5265-8830
Wenhao Tang *Department of Mathematics, Imperial College London, London, UK.
Zan Florjanic Baronik *Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK.
Holly Simpson Ragdale *Samantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK.ORCID 0000-0002-5848-8964
Roger OriaDepartment of Surgery, University of California, San Francisco, CA, USA.ORCID 0000-0002-5974-9775
Dimitrios VolterasDepartment of Mathematics, Imperial College London, London, UK.
Ian J WhiteLaboratory for Molecular Cell Biology, University College London, London, UK.
Gordon BeattieGenomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.
Imran UddinGenomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.ORCID 0000-0003-0736-3149
Tchern LennMicroscopy and Imaging Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.
Rachel LindsaySamantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK.
Sara Castro DevesaSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK.
Saketh R KaramchedSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK.
Mark F LythgoeUCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Vahid ShahrezaeiDepartment of Mathematics, Imperial College London, London, UK.ORCID 0000-0002-4013-5458
Valerie M WeaverDepartment of Surgery, University of California, San Francisco, CA, USA.ORCID 0000-0003-4786-6752
Ryoichi SugisawaDepartment of Biochemistry, Kindai University Faculty of Medicine, Osaka, Japan.ORCID 0000-0002-5912-5647
Federico RoncaroliGeoffrey Jefferson Brain Research Centre, Division of Neuroscience, School of Biology, Faculty of Biology, Medicine and Mental Health, University of Manchester, Manchester, UK.ORCID 0000-0003-3650-5572
Samuel MargueratGenomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.ORCID 0000-0002-2402-3165
Ciaran S HillSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK. ciaran.hill@ucl.ac.uk.ORCID 0000-0002-4488-4034
Simona ParrinelloSamantha Dickson Brain Cancer Unit, UCL Cancer Institute, London, UK. s.parrinello@ucl.ac.uk.ORCID 0000-0003-0820-6292

Funding

Tissue mechanics reprograms the tissue to malignancy and metastasisR35CA242447 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VALERIE MARIE WEAVER · 2020 to 2026
$6.6M
NCI NIH HHS R35 CA242447Wellcome Trust
6 · The paper itself

Abstract

Glioblastoma (GBM) is an aggressive and highly therapy-resistant brain tumour

Indexed as

AxonsBrain NeoplasmsDisease ProgressionGlioblastomaAnimalsArmadillo Domain ProteinsCell ProliferationCytoskeletal ProteinsFemaleHumansMaleMiceNeuroinflammatory DiseasesTumor MicroenvironmentWallerian DegenerationWhite MatterArmadillo Domain ProteinsCytoskeletal ProteinsSARM1 protein, mouse

Identifiers

PMID40836081
PMCPMC12507684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.