Evidence map›Paper›PMID 40836024›Full record

ArticleEuropean journal of human genetics : EJHG2025

MINDDS-connect: a federated data platform integrating biobanks for meta cohort building and analysis.

Benjamin Huremagic, Nishkala Sattanathan, Mathilde Geysens, Janet Harwood, Jente Verbesselt, Senne Meynants, Ann Swillen, Kris Van Den Bogaert, Danijela Drakulic, Goran Cuturilo and 12 more

Abstract read
In one paragraph

Article in European journal of human genetics : EJHG, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Unlocking Sensitive Data with SPHERE in the Age of AI.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Insights in genetics: from molecular mechanisms to patient perspectives.European journal of human genetics : EJHG · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Benjamin HuremagicLaboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, Belgium.ORCID 0009-0001-5198-1318
Nishkala SattanathanDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium.
Mathilde GeysensLaboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, Belgium.
Janet HarwoodNeuroscience and Mental Health Innovation Institute (NMHII), Cardiff University, Cardff, UK.ORCID 0000-0002-3225-0069
Jente VerbesseltLaboratory for Behavior and Neurodevelopment, Centre for Human Genetics, KU Leuven, Leuven, Belgium.ORCID 0000-0002-3024-8520
Senne MeynantsLaboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, Belgium.ORCID 0009-0006-7055-3737
Ann SwillenDepartment of Human Genetics, Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0003-4258-4537
Kris Van Den BogaertLaboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, Belgium.
Danijela DrakulicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Goran CuturiloFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Thérèse van AmelsvoortMental Health and Neuroscience Institute (MHeNs), Maastricht University, Maastricht, The Netherlands.
David LindenMental Health and Neuroscience Institute (MHeNs), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-5638-9292
Natália Oliva-TelesUnidade Local de Saúde de Santo António, Centro Hospitalar Universitário de Santo António, Porto, Portugal.ORCID 0000-0002-1295-3701
Paula JorgeUnidade Local de Saúde de Santo António, Centro Hospitalar Universitário de Santo António, Porto, Portugal.ORCID 0000-0002-6507-222X
Marianne B M van den BreeCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Jessica H HallCentre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.
Haleh ChizariDepartment of Human Genetics, Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Amin ArdeshirdavaniLaboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, Belgium.ORCID 0000-0002-7226-7324
Adrian J HarwoodNeuroscience and Mental Health Innovation Institute (NMHII), Cardiff University, Cardff, UK.
Geert VandeweyerDepartment of Medical Genetics, University of Antwerp, Antwerp, Belgium.
Yves MoreauESAT-STADIUS, KU Leuven, Leuven, Belgium.
Joris Robert VermeeschLaboratory of Cytogenetics and Genome Research, Centre for Human Genetics, KU Leuven, Leuven, Belgium. joris.vermeesch@uzleuven.be.ORCID 0000-0002-3071-1191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Access to large patient cohort data and biobanked resources is a catalyst for progress in genomics and biomedical research, increasing statistical power, and unlocking deeper insights-especially in areas like rare diseases and mental health. Responsible research necessitates maintenance of data privacy, regulatory compliance, and research standardization. It can appear that these guiding principles oppose each other and present barriers to responsible Open science. To address these critical challenges, we developed MINDDS-Connect, a federated data collaboration platform that integrates a web-based interface with decentralized Docker instances via a REST API. This architecture allows registered users to securely query samples across the platform's network, and offers a tool to facilitate the formation of virtual multi-centric meta-cohorts and research collaboration. MINDDS-Connect allows institutions to retain data control while enabling collaborative research and meta-cohort analysis through standardized metadata fields. Its implementation across five European centers enhanced the accessibility of 900 samples, demonstrating its effectiveness in enabling cohort construction and promoting collaborative research. The platform provides a secure, open-source solution consistent with EU Open Science policies, advancing large-scale mental health research.

Indexed as

Biological Specimen BanksSoftwareBiomedical ResearchCohort StudiesHumans

Identifiers

PMID40836024
PMCPMC12583608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.