ArticleBMC geriatrics2025
CT-based sarcopenia is independently associated with blood transfusions after hip arthroplasty in elderly patients with femoral neck fractures: a retrospective cohort study.
Article in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundComputed tomography (CT) based sarcopenia has been linked to postoperative complications in various surgeries. Although the associations between sarcopenia and femoral neck fractures (FNF) have received considerable attention, the relationship between sarcopenia and blood transfusions after hip arthroplasty in FNF patients remains unclear. This study aimed to investigate the relationship between CT-based sarcopenia and blood transfusions in elderly FNF patients after hip arthroplasty.
methodsA retrospective cohort study was conducted with 337 elderly FNF patients from September 2018 to January 2024. Basic demographic data, preoperative laboratory data, surgical data and chest CT data were collected. CT-based sarcopenia was diagnosed with gender-specific skeletal muscle index (SMI) cut-off values within the same ethnicity. Univariate and multivariate analyses were performed to identify independent risk factors for sarcopenia and blood transfusions in elderly FNF patients; receiver operating characteristic (ROC) curve analysis was used to determine the predictive cut-off value of SMI.
resultsAmong the 337 patients, 99 (29.4%) patients received blood transfusions, and 104 (30.9%) patients were diagnosed with CT-based sarcopenia. Sarcopenia patients had advanced age, lower body mass index (BMI), lower hemoglobin and lower serum albumin, with an increased likelihood of undergoing hemiarthroplasty (P < 0.05). Multivariate analysis revealed that advanced age (P = 0.002) and lower BMI (P < 0.001) were independently associated with CT-based sarcopenia. Patients who received transfusions had a lower BMI, lower hemoglobin, lower serum albumin, longer operation duration, greater intraoperative blood loss (IBL), and a greater incidence of sarcopenia (P < 0.05). Multivariate analysis revealed that sarcopenia (P = 0.006), lower hemoglobin (P < 0.001), longer operation duration (P = 0.022), and greater IBL (P < 0.001) were significantly associated with transfusion. ROC analysis revealed an optimal SMI cut-off of 23.0 cm²/m² for predicting transfusion, with 71.7% sensitivity and 71.0% specificity.
conclusionCT-based sarcopenia was independently associated with blood transfusions after hip arthroplasty in elderly FNF patients. In clinical practice, attention should be given to identifying it and implementing targeted interventions. LEVEL OF EVIDENCE: III, retrospective cohort study.
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