Evidence map›Paper›PMID 40835884›Full record

ArticleScientific reports2025

Chalcone constituents pulincisones A-F isolated from Pulicaria incisa with NQO1 inducer activity.

Ahmed R Hamed, Tarik A Mohamed, Sally A Abdel-Halim, Mohamed H Abd El-Razek, Sayed A El-Toumy, Maureen Higgins, Krystyna Skalicka-Woźniak, Albena T Dinkova-Kostova, Paul W Paré, Mahmoud M Sakr and 1 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ahmed R HamedChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt. ar.hamed@nrc.sci.eg.
Tarik A Mohamed *Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt.
Sally A Abdel-HalimChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt.
Mohamed H Abd El-Razek *Natural Compounds Chemistry Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt.
Sayed A El-ToumyDepartment of Chemistry of Tannins, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt.
Maureen HigginsDivision of Cellular and Systems Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
Krystyna Skalicka-WoźniakDepartment of Chemistry of Natural Products, Medical University of Lublin, Lublin, Poland.
Albena T Dinkova-KostovaDivision of Cellular and Systems Medicine, School of Medicine, Jacqui Wood Cancer Centre, University of Dundee, Dundee, DD1 9SY, Scotland, UK.
Paul W ParéDepartment of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX, 79409, USA.
Mahmoud M SakrDepartment of Plant Biotechnology, Institute of Genetic Engineering and Biotechnology, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt.
Mohamed-Elamir F HegazyChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt. me.fathy@nrc.sci.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously unknown chalcones such as β'-chalcanone-α,β-diols and a β-hydroxydihydrochalcone, named pulincisone A-F as well as known chalcone analogs 3,4,2',4',6',7,8-heptahydroxy-7(8)-dihydrochalcone (7) and 4,2',6'-trihydroxy-4'-methoxydihydrochalcone (8) were isolated from Pulicaria incisa (Lam.) DC. and assayed for cancer preventative activity. Structures were identified by spectroscopic methods, including HRESIMS, 1D and 2D NMR experiments. Pulincisone A and B, are epimers, at stereocenter C-8. A structural revision resulted in pulicisone A (1) and D (4) replacing pulichalconoids B and C, that were previously reported from the same species. Isolated chalcones were assessed for chemopreventive potential as inducers of NAD(P)H: quinone oxidoreductase 1 (NQO1). Compounds 2, 3, 5, and 6 induced NQO1, using a Prochaska assay. NQO1 protein expression was detected by Western blotting analysis. Compound 6 among four active compounds had the highest potency as NQO1 inducers. Molecular docking analysis of the NQO1 Keap1 Kelch domain suggests Nrf2-dependent induction. These data indicate that pulincisone F (6) is a promising bioactive antioxidant (NQO1-inducer) with superior docking scores with the Keap1-Nrf2 complex compared to the reference NQO1 inducer sulforaphane (- 8.26 versus - 5.08 kcal mol

Indexed as

ChalconeChalconesNAD(P)H Dehydrogenase (Quinone)HumansKelch-Like ECH-Associated Protein 1Molecular Docking SimulationNF-E2-Related Factor 2ChalconeChalconesKelch-Like ECH-Associated Protein 1NAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2NQO1 protein, humanAntioxidantAsteraceaeChemopreventiveDihydrochalconeNQO1Pulicaria incisa (Lam.) DC.

Identifiers

PMID40835884
PMCPMC12368085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.