ArticleScientific reports2025
Symmetric dimethylarginine as a biomarker of renal impairment after a decade of follow-up.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Circulating nitric oxide pathway metabolites in heart failure with preserved ejection fraction: a sex-stratified cross-sectional analysis.Biology of sex differences · 2026Trial
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8 authors.
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Abstract
Chronic kidney disease (CKD) is characterized by a gradual and irreversible decline in renal function. Arginine derivatives like symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA) have been associated with the progression of renal disease in cross-sectional studies. This study aimed to investigate the longitudinal associations between arginine derivatives and renal function over time in a population-based cohort. Data were derived from the Study of Health in Pomerania-START (SHIP-START-0, n = 3100, mean age 49 years, women 51.3%). The 5-year follow-up included 2174 and the 10-year follow-up 1657 individuals. At baseline, serum concentrations of Arg, ADMA, SDMA and homoarginine were measured using liquid chromatography-tandem mass spectrometry, while renal parameters (creatinine and cystatin C) were quantified at baseline, 5- and 10-year follow-up. Three different statistical analyses (linear regression, logistic regression, analyses of covariance (ANCOVA)), were performed to investigate the longitudinal associations between baseline levels of Arg, ADMA, SMDA and homoarginine as exposure and renal function parameters as outcome. The results showed a significantly inverse longitudinal association between SDMA and renal function. Specifically, a one μmol/l greater SDMA was related to an odds ratio of 1.77 (95% confidence interval (CI) 1.41; 2.21) at 5-year follow-up and 1.43 (95% CI 1.11; 1.84) at 10-year follow-up for kidney dysfunction defined as estimated glomerular filtration rate less than 60 ml/min/1.73 m
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