Evidence map›Paper›PMID 40835809›Full record

ReviewClinical journal of gastroenterology2025

Repeated lymph-node recurrences after radical endoscopic submucosal dissection in a patient of esophageal squamous cell carcinoma, judged as pT1a-LPM: a case report and literature review.

Kosuke Hirose, Noriaki Sadanaga, Seiya Kato, Daisuke Yoshimura, Yuta Sokabe, Shun Sasaki, Takuya Honbo, Yasuo Tsuda, Hiroshi Matsuura, Koshi Mimori

Abstract readCase ReportsReview
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In one paragraph

Review in Clinical journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kosuke HiroseDepartment of Surgery, Kyushu University Beppu Hospital, Tsurumibara 4546, Beppu-Shi, Oita, 874-0838, Japan.ORCID http://orcid.org/0000-0003-1645-7382
Noriaki SadanagaDepartment of Surgery, Saiseikai Fukuoka General Hospital, Tenjin 1-3-46, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-0001, Japan.
Seiya KatoDivision of Pathology, Saiseikai Fukuoka General Hospital, Tenjin 1-3-46, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-0001, Japan.
Daisuke YoshimuraDepartment of Gastroenterology, National Hospital Organization, Kyushu Medical Center, Jigyohama 1-8-1, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-8563, Japan.
Yuta SokabeDepartment of Surgery, Saiseikai Fukuoka General Hospital, Tenjin 1-3-46, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-0001, Japan.
Shun SasakiDepartment of Surgery, Saiseikai Fukuoka General Hospital, Tenjin 1-3-46, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-0001, Japan.
Takuya HonboDepartment of Surgery, Saiseikai Fukuoka General Hospital, Tenjin 1-3-46, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-0001, Japan.
Yasuo TsudaDepartment of Surgery, Kyushu University Beppu Hospital, Tsurumibara 4546, Beppu-Shi, Oita, 874-0838, Japan.
Hiroshi MatsuuraDepartment of Surgery, Saiseikai Fukuoka General Hospital, Tenjin 1-3-46, Chuo-Ku, Fukuoka-Shi, Fukuoka, 810-0001, Japan.
Koshi MimoriDepartment of Surgery, Kyushu University Beppu Hospital, Tsurumibara 4546, Beppu-Shi, Oita, 874-0838, Japan. mimori.koshi.791@m.kyushu-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Esophageal squamous cell carcinoma confined to the depth of the T1a-epithelium and lamina propria mucosa rarely exhibits lymph node and distant organ metastases; therefore, the recommended therapy for such cases is endoscopic resection. Furthermore, once esophageal squamous cell carcinoma recurs after curative treatment, including endoscopic mucosal dissection, a unified treatment method cannot be established, because recurrence patterns vary from case to case. Herein, we present an unusual case of metachronous locoregional and subclavian lymph-node recurrence following repeated radical endoscopic submucosal dissection of the superficial esophageal squamous cell carcinoma judged as T1a-LPM with deep subepithelial stromal invasion. The patient was treated using a multidisciplinary approach, leading to a cancer-free status. Although recurrent lymph-node metastasis after curative endoscopic submucosal dissection for pT1a-LPM esophageal squamous cell carcinoma is rare, it is possible. A comprehensive and detailed analysis of the risk factors of recurrence after endoscopic resection for pT1a-LPM cases is required, and appropriate follow-up strategies and stratified adjuvant therapies should be selected for high-risk patients.

Indexed as

Carcinoma, Squamous CellEndoscopic Mucosal ResectionEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaNeoplasm Recurrence, LocalAgedHumansLymphatic MetastasisMaleMiddle AgedNeoplasm StagingEndoscopic submucosal dissectionEsophageal squamous cell carcinomaLymph-node recurrenceMultimodal therapypT1a-LPM

Identifiers

PMID40835809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.