Evidence map›Paper›PMID 40835779›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025

The evolution of axial postural abnormality in Parkinson's disease: a 3-year longitudinal observational study.

Zhuang Wu, Ronghua Hong, Zhuoyu Zhang, Sha Zhu, Yanzi Peng, Jingxing Zhang, Qiang Guan, Lizhen Pan, Yuhui Chen, Lingjing Jin

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Efficacy and safety ofBMC neurology · 2026
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhuang Wu *Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Sunshine Rehabilitation Center), School of Medicine, Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China.ORCID http://orcid.org/0000-0002-0491-2416
Ronghua Hong *Department of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Sunshine Rehabilitation Center), School of Medicine, Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China.
Zhuoyu Zhang *Neurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Sha ZhuDepartment of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Sunshine Rehabilitation Center), School of Medicine, Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China.
Yanzi PengNeurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Jingxing ZhangNeurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Qiang GuanNeurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Lizhen PanNeurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Yuhui ChenNeurotoxin Research Center, Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Neurology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China. chenyuhui2005@126.com.
Lingjing JinDepartment of Neurology and Neurological Rehabilitation, Shanghai Disabled Persons' Federation Key Laboratory of Intelligent Rehabilitation Assistive Devices and Technologies, Shanghai Sunshine Rehabilitation Center), School of Medicine, Yangzhi Rehabilitation Hospital, Tongji University, Shanghai, China. lingjingjin@tongji.edu.cn.

Funding

Clinical Technology Innovation Project of Shanghai Shenkang Hospital Development Center SHDC12020119Mechanism study of visual-motor integration network regulation of postural abnormalities in Parkinson's disease 82201404National Clinical Key Specialty Construction Project of China Z155080000004National Key Research and Development Program 2023YFC3604500/2023YFC3604505Science and Technology Innovation Program of Shanghai Municipal Science and Technology 22Y31900200 and 22Y31900203Shanghai Clinical Research Ward SHDC2023CRW018BShanghai Hospital Development Center Foundation-Shanghai Municipal Hospital Rehabilitation Medicine Specialty Alliance SHDC22023304Shanghai Rehabilitation Medical Research Center (Top Priority Research Center of Shanghai) 2023ZZ02027
6 · The paper itself

Abstract

introductionAxial postural abnormality (APA) contains various forms and the progression patterns and clinical predictors for each APA remain unknown. We aimed to investigate the evolution of APA and elucidate its relationships to clinical picture in Parkinson's disease (PD).

methods151 PD patients underwent anterior neck flexion (ANF), anterior trunk flexion (ATF) at thoracic and lumbar fulcrum, and lateral trunk flexion (LTF) assessments for 3 years. APA was assessed using a linear mixed-effects model. The cumulative incidence of APA progression was displayed using Kaplan-Meier curves with log-rank test to compare differences. Univariate and multivariate Cox proportional hazards analyses were performed to investigate risk factors for different types of APA progression.

resultsANF and ATF (thoracic fulcrum) began to increase significantly at 1-year follow-up. Lumbar fulcrum (ATF) and LTF began increasing at the 2-year and 3-year follow-ups, respectively. The overall cumulative progression risks for four APAs were different, with ANF having a significantly higher risk than thoracic fulcrum (ATF) and lumbar fulcrum (ATF), followed by LTF. We identified predictors for ANF progression were disease duration and bradykinesia symptoms. Exercise status and bradykinesia symptoms were associated with progression of ATF (thoracic fulcrum), and Hoehn-Yahr stage was associated with progression of ATF (lumbar fulcrum). LTF progression was associated with levodopa equivalent daily dose and MDS-UPDRS III posture subitem.

conclusionThe APA of PD patients follow a "top to down, sagittal to coronal plane" pattern. An increased APA is associated with motor symptoms. Regular physical activity can slow the deterioration of APA in PD.

Indexed as

Parkinson DiseasePostural BalanceAgedDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedAxial postural abnormalitiesMotor symptomsNon-motor symptomsParkinson’s diseaseProgression

Identifiers

PMID40835779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.